Thromboembolic risk with IVIg: Incidence and risk factors in patients with inflammatory neuropathy.
Anemia, Hemolytic, Autoimmune
/ therapy
Ataxia
/ therapy
Humans
Immunoglobulins, Intravenous
/ therapeutic use
Immunologic Factors
/ therapeutic use
Incidence
Myocardial Infarction
/ epidemiology
Ophthalmoplegia
/ therapy
Polyneuropathies
/ therapy
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
/ therapy
Pulmonary Embolism
/ epidemiology
Retrospective Studies
Risk Factors
Small Fiber Neuropathy
/ therapy
Stroke
/ epidemiology
Superior Vena Cava Syndrome
/ epidemiology
Thromboembolism
/ epidemiology
Venous Thrombosis
/ epidemiology
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
10
01
2019
accepted:
15
08
2019
pubmed:
20
12
2019
medline:
19
5
2020
entrez:
20
12
2019
Statut:
ppublish
Résumé
Our objective was to evaluate whether IV immunoglobulin (IVIg) increases the risk of thromboembolic events in neurology outpatients with inflammatory neuropathies, as there is conflicting evidence supporting this hypothesis, mainly from non-neurologic cohorts. We investigated this question over 30 months in our cohort of patients with inflammatory neuropathies receiving regular IVIg and found a greater incidence of arterial and venous thromboembolic events than population-based rates determined by hospital admissions data. Vascular risk factors were more common in the event group but there were no IVIg administration factors that contributed to the risk. This study suggests that IVIg may have a small but contributory role in determining thromboembolic risk in the inflammatory neuropathy cohort and more evidence is required before it is clear whether the current primary prevention guidelines are appropriate in this group of patients.
Identifiants
pubmed: 31852814
pii: WNL.0000000000008742
doi: 10.1212/WNL.0000000000008742
pmc: PMC7136065
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e635-e638Informations de copyright
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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