[Association of the TCF7L2 (RS7903146) genotype with adiposity and metabolic markers in the Chilean adult population].
Asociación del polimorfismo rs7903146, del gen TCF7L2, con marcadores de adiposidad y metabólicos en población chilena - resultados del estudio GENADIO.
Adiposity
/ ethnology
Adult
Alleles
Anthropometry
Blood Glucose
/ genetics
Chile
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Markers
Genotype
Humans
Linear Models
Male
Middle Aged
Nutritional Status
Polymorphism, Single Nucleotide
Reference Values
Risk Factors
Transcription Factor 7-Like 2 Protein
/ genetics
Young Adult
Journal
Revista medica de Chile
ISSN: 0717-6163
Titre abrégé: Rev Med Chil
Pays: Chile
ID NLM: 0404312
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
15
07
2018
accepted:
07
08
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
25
2
2020
Statut:
ppublish
Résumé
Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population. The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin). There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p = 0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p = 0.04)]. There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome. These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.
Sections du résumé
BACKGROUND
BACKGROUND
Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association.
AIM
OBJECTIVE
To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population.
MATERIAL AND METHODS
METHODS
The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin).
RESULTS
RESULTS
There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p = 0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p = 0.04)]. There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome.
CONCLUSIONS
CONCLUSIONS
These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.
Identifiants
pubmed: 31859960
pii: S0034-98872019000800965
doi: 10.4067/S0034-98872019000800965
pii:
doi:
Substances chimiques
Blood Glucose
0
Genetic Markers
0
TCF7L2 protein, human
0
Transcription Factor 7-Like 2 Protein
0
Types de publication
Journal Article
Langues
spa
Sous-ensembles de citation
IM