Vitamin B Complex Treatment Attenuates Local Inflammation after Peripheral Nerve Injury.
Anti-Inflammatory Agents
/ pharmacology
Calcium
/ metabolism
Calcium Channels
/ genetics
Cytokines
/ metabolism
Fluorescent Antibody Technique
Gene Expression Regulation
Inflammation
/ drug therapy
Macrophage Activation
/ drug effects
Macrophages
/ drug effects
Peripheral Nerve Injuries
/ drug therapy
Vitamin B Complex
/ pharmacology
M1/M2 macrophages
calcium channels
neuroinflammation
peripheral nerve injury
regeneration
vitamin B complex therapy
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Dec 2019
17 Dec 2019
Historique:
received:
18
10
2019
revised:
02
12
2019
accepted:
13
12
2019
entrez:
22
12
2019
pubmed:
22
12
2019
medline:
12
5
2020
Statut:
epublish
Résumé
Peripheral nerve injury (PNI) leads to a series of cellular and molecular events necessary for axon regeneration and reinnervation of target tissues, among which inflammation is crucial for the orchestration of all these processes. Macrophage activation underlies the pathogenesis of PNI and is characterized by morphological/phenotype transformation from proinflammatory (M1) to an anti-inflammatory (M2) type with different functions in the inflammatory and reparative process. The aim of this study was to evaluate influence of the vitamin B (B1, B2, B3, B5, B6, and B12) complex on the process of neuroinflammation that is in part regulated by l-type Ca
Identifiants
pubmed: 31861069
pii: molecules24244615
doi: 10.3390/molecules24244615
pmc: PMC6943485
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Calcium Channels
0
Cytokines
0
Vitamin B Complex
12001-76-2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : III41014 and ON175033
Organisme : Ministry of Defense of the Republic of Serbia
ID : MFVMA/10/13-15 and MFVMA/10/16-18
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