Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages.

DNA, Single-Stranded Oligonucleotides Oligonucleotides, Antisense RNA Ribonuclease H / metabolism

Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
21 02 2020
Historique:
pubmed: 24 12 2019
medline: 24 6 2021
entrez: 24 12 2019
Statut: ppublish

Résumé

Ethynylphosphonate (EP)-linked thymidine dimers were synthesized via a palladium-catalyzed cross-coupling reaction and successfully incorporated into oligonucleotides. The oligonucleotides containing EP linkages appropriately formed a duplex with their complementary single-stranded RNA (ssRNA) and single-stranded DNA. The oligonucleotides containing both the EP linkages and 2'-

Identifiants

DOI: 10.1021/acs.joc.9b01318 PMID: 31867976
pubmed: 31867976
doi: 10.1021/acs.joc.9b01318
doi:

Substances chimiques

DNA, Single-Stranded 0
Oligonucleotides 0
Oligonucleotides, Antisense 0
RNA 63231-63-0
Ribonuclease H EC 3.1.26.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1794-1801

Auteurs

Masahiko Horiba (M)

Graduate School of Pharmaceutical Sciences , Osaka University , 1-6 Yamadaoka , Suita , Osaka 565-0871 , Japan.

Takao Yamaguchi (T)

Graduate School of Pharmaceutical Sciences , Osaka University , 1-6 Yamadaoka , Suita , Osaka 565-0871 , Japan.
ORCID: 0000-0003-3180-0257

Satoshi Obika (S)

Graduate School of Pharmaceutical Sciences , Osaka University , 1-6 Yamadaoka , Suita , Osaka 565-0871 , Japan.
ORCID: 0000-0002-6842-6812

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN simple brin › Synthesis and Properties of Oligonucleotides...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Synthesis and Properties of Oligonucleotides...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Éléments antisens (génétique) › Oligonucléotides antisens › Synthesis and Properties of Oligonucleotides...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Synthesis and Properties of Oligonucleotides...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Ribonuclease H › Synthesis and Properties of Oligonucleotides...