Indirect sexual selection drives rapid sperm protein evolution in abalone.
NMR spectroscopy
abalone
evolutionary biology
fertilization
molecular biophysics
rapid evolution
sexual selection
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 12 2019
23 12 2019
Historique:
received:
10
10
2019
accepted:
20
12
2019
pubmed:
24
12
2019
medline:
13
6
2020
entrez:
24
12
2019
Statut:
epublish
Résumé
Sexual selection can explain the rapid evolution of fertilization proteins, yet sperm proteins evolve rapidly even if not directly involved in fertilization. In the marine mollusk abalone, sperm secrete enormous quantities of two rapidly evolving proteins, lysin and sp18, that are stored at nearly molar concentrations. We demonstrate that this extraordinary packaging is achieved by associating into Fuzzy Interacting Transient Zwitterion (FITZ) complexes upon binding the intrinsically disordered FITZ Anionic Partner (FITZAP). FITZ complexes form at intracellular ionic strengths and, upon exocytosis into seawater, lysin and sp18 are dispersed to drive fertilization. NMR analyses revealed that lysin uses a common molecular interface to bind both FITZAP and its egg receptor VERL. As sexual selection alters the lysin-VERL interface, FITZAP coevolves rapidly to maintain lysin binding. FITZAP-lysin interactions exhibit a similar species-specificity as lysin-VERL interactions. Thus, tethered molecular arms races driven by sexual selection can generally explain rapid sperm protein evolution.
Identifiants
pubmed: 31868593
doi: 10.7554/eLife.52628
pii: 52628
pmc: PMC6952181
doi:
pii:
Substances chimiques
Egg Proteins
0
Mucoproteins
0
Proteins
0
lysin, gastropoda
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : K99 HD090201
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD076862
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : K99-HD090201
Pays : International
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01-HD076862
Pays : International
Informations de copyright
© 2019, Wilburn et al.
Déclaration de conflit d'intérêts
DW, LT, RK, WS No competing interests declared
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