Rachel E Klevit

Affiliations

Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.

Publications (28)

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core.

PLoS pathogens

Avec: Dagmara I Kisiela , Pearl Magala , Gianluca Interlandi , Laura A Carlucci , Angelo Ramos , Veronika Tchesnokova , Benjamin Basanta , Vladimir Yarov-Yarovoy , Hovhannes Avagyan , Anahit Hovhannisyan , Wendy E Thomas , Ronald E Stenkamp , Rachel E Klevit , Evgeni V Sokurenko

Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability.

Nature chemical biology

Avec: Juliana Ferreira de Oliveira , Paula Favoretti Vital do Prado , Silvia Souza da Costa , Mauricio Luis Sforça , Camila Canateli , Americo Tavares Ranzani , Mariana Maschietto , Paulo Sergio Lopes de Oliveira , Paulo A Otto , Rachel E Klevit , Ana Cristina Victorino Krepischi , Carla Rosenberg , Kleber Gomes Franchini

Release of a disordered domain enhances HspB1 chaperone activity toward tau.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Hannah E R Baughman , Thanh-Hau T Pham , Chloe S Adams , Abhinav Nath , Rachel E Klevit

Edmond Fischer (1920-2021).

Science (New York, N.Y.)

Avec: John D Scott , Trisha N Davis , Rachel E Klevit , William A Catterall

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.

Nature structural & molecular biology

Avec: Samuel R Witus , Anika L Burrell , Daniel P Farrell , Jianming Kang , Meiling Wang , Jesse M Hansen , Alex Pravat , Lisa M Tuttle , Mikaela D Stewart , Peter S Brzovic , Champak Chatterjee , Weixing Zhao , Frank DiMaio , Justin M Kollman , Rachel E Klevit

RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain.

Proteins

Avec: Pearl Magala , Rachel E Klevit , Wendy E Thomas , Evgeni V Sokurenko , Ronald E Stenkamp

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

The EMBO journal

Avec: Samuel R Witus , Lisa M Tuttle , Wenjing Li , Alex Zelter , Meiling Wang , Klaiten E Kermoade , Damien B Wilburn , Trisha N Davis , Peter S Brzovic , Weixing Zhao , Rachel E Klevit

Disordered region encodes α-crystallin chaperone activity toward lens client γD-crystallin.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Christopher N Woods , Lindsey D Ulmer , Miklos Guttman , Matthew F Bush , Rachel E Klevit

High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid.

Journal of proteome research

Avec: Lindsey D Ulmer , Daniele Canzani , Christopher N Woods , Natalie L Stone , Maria K Janowska , Rachel E Klevit , Matthew F Bush

Small heat shock proteins: multifaceted proteins with important implications for life.

Cell stress & chaperones

Avec: Serena Carra , Simon Alberti , Justin L P Benesch , Wilbert Boelens , Johannes Buchner , John A Carver , Ciro Cecconi , Heath Ecroyd , Nikolai Gusev , Lawrence E Hightower , Rachel E Klevit , Hyun O Lee , Krzysztof Liberek , Brent Lockwood , Angelo Poletti , Vincent Timmerman , Melinda E Toth , Elizabeth Vierling , Tangchun Wu , Robert M Tanguay

The ubiquitin ligase SspH1 from

The Journal of biological chemistry

Avec: Matt Cook , Scott P Delbecq , Thomas P Schweppe , Miklos Guttman , Rachel E Klevit , Peter S Brzovic

HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner.

The Journal of biological chemistry

Avec: Scott P Delbecq , Rachel E Klevit

Indirect sexual selection drives rapid sperm protein evolution in abalone.

eLife

Avec: Damien Beau Wilburn , Lisa M Tuttle , Rachel E Klevit , Willie J Swanson

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of 'quasi-ordered' states.

eLife

Avec: Amanda F Clouser , Hannah Er Baughman , Benjamin Basanta , Miklos Guttman , Abhinav Nath , Rachel E Klevit

Peeking from behind the veil of enigma: emerging insights on small heat shock protein structure and function.

Cell stress & chaperones

Avec: Rachel E Klevit

Mechanisms of Small Heat Shock Proteins.

Cold Spring Harbor perspectives in biology

Avec: Maria K Janowska , Hannah E R Baughman , Christopher N Woods , Rachel E Klevit

UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.

Biochemistry

Avec: Adam Kanack , Vinayak Vittal , Holly Haver , Theodore Keppel , Rebekah L Gundry , Rachel E Klevit , Kenneth Matthew Scaglione

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation.

The EMBO journal

Avec: Christian Lips , Tobias Ritterhoff , Annika Weber , Maria K Janowska , Mandy Mustroph , Thomas Sommer , Rachel E Klevit

Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4.

Nature communications

Avec: Lisa M Tuttle , Derek Pacheco , Linda Warfield , Damien B Wilburn , Steven Hahn , Rachel E Klevit

The BRCA1/BARD1 ubiquitin ligase and its substrates.

The Biochemical journal

Avec: Samuel R Witus , Mikaela D Stewart , Rachel E Klevit

BRCA1/BARD1 is a nucleosome reader and writer.

Trends in biochemical sciences

Avec: Samuel R Witus , Weixing Zhao , Peter S Brzovic , Rachel E Klevit

Cbl interacts with multiple E2s in vitro and in cells.

PloS one

Avec: Mariya S Liyasova , Ke Ma , Donna Voeller , Philip E Ryan , Jinqiu Chen , Rachel E Klevit , Stanley Lipkowitz

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.

Nature communications

Avec: Kedar Puvar , Shalini Iyer , Jiaqi Fu , Sebastian Kenny , Kristos I Negrón Terón , Zhao-Qing Luo , Peter S Brzovic , Rachel E Klevit , Chittaranjan Das

A native chemical chaperone in the human eye lens.

eLife

Avec: Eugene Serebryany , Sourav Chowdhury , Christopher N Woods , David C Thorn , Nicki E Watson , Arthur A McClelland , Rachel E Klevit , Eugene I Shakhnovich

Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain.

Structure (London, England : 1993)

Avec: Katherine H Reiter , Alex Zelter , Maria K Janowska , Michael Riffle , Nicholas Shulman , Brendan X MacLean , Kaipo Tamura , Matthew C Chambers , Michael J MacCoss , Trisha N Davis , Miklos Guttman , Peter S Brzovic , Rachel E Klevit

Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.

Nucleic acids research

Avec: Ishor Thapa , Russell Vahrenkamp , Samuel R Witus , Caitlin Lightle , Owen Falkenberg , Marlo K Sellin Jeffries , Rachel E Klevit , Mikaela D Stewart

Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.

Molecular cell

Avec: Meiling Wang , Wenjing Li , Nozomi Tomimatsu , Corey H Yu , Jae-Hoon Ji , Salvador Alejo , Samuel R Witus , Dauren Alimbetov , O'Taveon Fitzgerald , Bo Wu , Qijing Wang , Yuxin Huang , Yaqi Gan , Felix Dong , Youngho Kwon , Gangadhara R Sareddy , Tyler J Curiel , Amyn A Habib , Robert Hromas , Carolina Dos Santos Passos , Tingting Yao , Dmitri N Ivanov , Peter S Brzovic , Sandeep Burma , Rachel E Klevit , Weixing Zhao

HDXBoxeR: An R package for statistical analysis and visualization of multiple Hydrogen-Deuterium Exchange Mass-Spectrometry datasets of different protein states.

Bioinformatics (Oxford, England)

Avec: Maria K Janowska , Katherine Reiter , Pearl Magala , Miklos Guttman , Rachel E Klevit

Réseau de co-auteurs

Peter S Brzovic 7 collaborations

Samuel R Witus 6 collaborations

Miklos Guttman 5 collaborations

Maria K Janowska 5 collaborations

Lisa M Tuttle 4 collaborations

Weixing Zhao 4 collaborations

Christopher N Woods 4 collaborations

Pearl Magala 3 collaborations

Trisha N Davis 3 collaborations

Meiling Wang 3 collaborations

Mikaela D Stewart 3 collaborations

Benjamin Basanta 2 collaborations

Wendy E Thomas 2 collaborations

Ronald E Stenkamp 2 collaborations

Evgeni V Sokurenko 2 collaborations

Hannah E R Baughman 2 collaborations

Abhinav Nath 2 collaborations

Wenjing Li 2 collaborations

Alex Zelter 2 collaborations

Damien B Wilburn 2 collaborations

Lindsey D Ulmer 2 collaborations

Matthew F Bush 2 collaborations

Scott P Delbecq 2 collaborations

Dagmara I Kisiela 1 collaboration

Gianluca Interlandi 1 collaboration

Laura A Carlucci 1 collaboration

Angelo Ramos 1 collaboration

Veronika Tchesnokova 1 collaboration

Vladimir Yarov-Yarovoy 1 collaboration

Hovhannes Avagyan 1 collaboration

Anahit Hovhannisyan 1 collaboration

Juliana Ferreira de Oliveira 1 collaboration

Paula Favoretti Vital do Prado 1 collaboration

Silvia Souza da Costa 1 collaboration

Mauricio Luis Sforça 1 collaboration

Camila Canateli 1 collaboration

Americo Tavares Ranzani 1 collaboration

Mariana Maschietto 1 collaboration

Paulo Sergio Lopes de Oliveira 1 collaboration

Paulo A Otto 1 collaboration

Ana Cristina Victorino Krepischi 1 collaboration

Carla Rosenberg 1 collaboration

Kleber Gomes Franchini 1 collaboration

Thanh-Hau T Pham 1 collaboration

Chloe S Adams 1 collaboration

John D Scott 1 collaboration

William A Catterall 1 collaboration

Anika L Burrell 1 collaboration

Daniel P Farrell 1 collaboration

Jianming Kang 1 collaboration

Jesse M Hansen 1 collaboration

Alex Pravat 1 collaboration

Champak Chatterjee 1 collaboration

Frank DiMaio 1 collaboration

Justin M Kollman 1 collaboration

Klaiten E Kermoade 1 collaboration

Daniele Canzani 1 collaboration

Natalie L Stone 1 collaboration

Serena Carra 1 collaboration

Simon Alberti 1 collaboration

Justin L P Benesch 1 collaboration

Wilbert Boelens 1 collaboration

Johannes Buchner 1 collaboration

John A Carver 1 collaboration

Ciro Cecconi 1 collaboration

Heath Ecroyd 1 collaboration

Nikolai Gusev 1 collaboration

Lawrence E Hightower 1 collaboration

Hyun O Lee 1 collaboration

Krzysztof Liberek 1 collaboration

Brent Lockwood 1 collaboration

Angelo Poletti 1 collaboration

Vincent Timmerman 1 collaboration

Melinda E Toth 1 collaboration

Elizabeth Vierling 1 collaboration

Tangchun Wu 1 collaboration

Robert M Tanguay 1 collaboration

Matt Cook 1 collaboration

Thomas P Schweppe 1 collaboration

Damien Beau Wilburn 1 collaboration

Willie J Swanson 1 collaboration

Amanda F Clouser 1 collaboration

Hannah Er Baughman 1 collaboration

Adam Kanack 1 collaboration

Vinayak Vittal 1 collaboration

Holly Haver 1 collaboration

Theodore Keppel 1 collaboration

Rebekah L Gundry 1 collaboration

Kenneth Matthew Scaglione 1 collaboration

Christian Lips 1 collaboration

Tobias Ritterhoff 1 collaboration

Annika Weber 1 collaboration

Mandy Mustroph 1 collaboration

Thomas Sommer 1 collaboration

Derek Pacheco 1 collaboration

Linda Warfield 1 collaboration

Steven Hahn 1 collaboration

Mariya S Liyasova 1 collaboration

Ke Ma 1 collaboration

Donna Voeller 1 collaboration

Philip E Ryan 1 collaboration

Jinqiu Chen 1 collaboration

Stanley Lipkowitz 1 collaboration

Kedar Puvar 1 collaboration

Shalini Iyer 1 collaboration

Jiaqi Fu 1 collaboration

Sebastian Kenny 1 collaboration

Kristos I Negrón Terón 1 collaboration

Zhao-Qing Luo 1 collaboration

Chittaranjan Das 1 collaboration

Eugene Serebryany 1 collaboration

Sourav Chowdhury 1 collaboration

David C Thorn 1 collaboration

Nicki E Watson 1 collaboration

Arthur A McClelland 1 collaboration

Eugene I Shakhnovich 1 collaboration

Katherine H Reiter 1 collaboration

Michael Riffle 1 collaboration

Nicholas Shulman 1 collaboration

Brendan X MacLean 1 collaboration

Kaipo Tamura 1 collaboration

Matthew C Chambers 1 collaboration

Michael J MacCoss 1 collaboration

Ishor Thapa 1 collaboration

Russell Vahrenkamp 1 collaboration

Caitlin Lightle 1 collaboration

Owen Falkenberg 1 collaboration

Marlo K Sellin Jeffries 1 collaboration

Nozomi Tomimatsu 1 collaboration

Corey H Yu 1 collaboration

Jae-Hoon Ji 1 collaboration

Salvador Alejo 1 collaboration

Dauren Alimbetov 1 collaboration

O'Taveon Fitzgerald 1 collaboration

Bo Wu 1 collaboration

Qijing Wang 1 collaboration

Yuxin Huang 1 collaboration

Yaqi Gan 1 collaboration

Felix Dong 1 collaboration

Youngho Kwon 1 collaboration

Gangadhara R Sareddy 1 collaboration

Tyler J Curiel 1 collaboration

Amyn A Habib 1 collaboration

Robert Hromas 1 collaboration

Carolina Dos Santos Passos 1 collaboration

Tingting Yao 1 collaboration

Dmitri N Ivanov 1 collaboration

Sandeep Burma 1 collaboration

Katherine Reiter 1 collaboration