Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Bacterial Proteins
/ genetics
Catalytic Domain
/ genetics
Cloning, Molecular
Crystallography, X-Ray
Legionella pneumophila
/ enzymology
Models, Molecular
Mutagenesis, Site-Directed
Protein Binding
Protein Structure, Tertiary
Recombinant Proteins
/ genetics
Substrate Specificity
Transglutaminases
/ genetics
Ubiquitin
/ isolation & purification
Ubiquitin-Conjugating Enzymes
/ isolation & purification
Ubiquitination
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 05 2020
12 05 2020
Historique:
received:
24
10
2019
accepted:
14
04
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
1
9
2020
Statut:
epublish
Résumé
The bacterial effector MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiquitin ligation, catalyzing formation of a γ-glutamyl-ε-Lys (Gln40
Identifiants
pubmed: 32398758
doi: 10.1038/s41467-020-16211-x
pii: 10.1038/s41467-020-16211-x
pmc: PMC7217864
doi:
Substances chimiques
Bacterial Proteins
0
Recombinant Proteins
0
Ubiquitin
0
Transglutaminases
EC 2.3.2.13
UBE2N protein, human
EC 2.3.2.23
Ubiquitin-Conjugating Enzymes
EC 2.3.2.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2365Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM088055
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126296
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM132024
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127465
Pays : United States
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