Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins.
CDR3
TCR repertoire
genetics
thymic selection
twins
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
10
09
2019
revised:
04
11
2019
accepted:
20
12
2019
pubmed:
25
12
2019
medline:
29
10
2020
entrez:
25
12
2019
Statut:
ppublish
Résumé
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
Identifiants
pubmed: 31872865
doi: 10.1002/eji.201948404
doi:
Substances chimiques
Complementarity Determining Regions
0
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
748-751Subventions
Organisme : University of Helsinki Research Foundation
Pays : International
Organisme : Emil Aaltonen Foundation
Pays : International
Organisme : Biomedicum Helsinki Foundation
Pays : International
Organisme : University of Helsinki
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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