No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
received:
02
08
2019
accepted:
08
12
2019
entrez:
26
12
2019
pubmed:
26
12
2019
medline:
4
11
2020
Statut:
epublish
Résumé
The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
Identifiants
pubmed: 31875016
doi: 10.1038/s41598-019-56240-1
pii: 10.1038/s41598-019-56240-1
pmc: PMC6930283
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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