Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment.
Animals
Bystander Effect
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Dendritic Cells
/ metabolism
Humans
Immunologic Memory
Interferon-gamma
/ biosynthesis
Interleukin-12
/ metabolism
Interleukin-18
/ metabolism
Lung
/ immunology
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Infiltration
/ immunology
Pneumonia, Bacterial
/ immunology
Severity of Illness Index
Resident memory T cell
bystander activation
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
received:
23
07
2019
revised:
22
10
2019
accepted:
25
11
2019
entrez:
26
12
2019
pubmed:
26
12
2019
medline:
29
9
2020
Statut:
ppublish
Résumé
Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release cytokines in response to local cognate antigen recognition, which in turn, draws circulating immune cells into the tissue. Here, we show noncognate, bystander activation can also trigger the sensing and alarming function of pulmonary CD8
Identifiants
pubmed: 31875535
pii: S2211-1247(19)31603-1
doi: 10.1016/j.celrep.2019.11.103
pii:
doi:
Substances chimiques
Interleukin-18
0
Interleukin-12
187348-17-0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4236-4244.e3Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.