White Matter Integrity Underlying Depressive Symptoms in Dementia Caregivers.
Aged
Caregivers
/ psychology
Dementia
/ therapy
Depression
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Female
Gyrus Cinguli
/ pathology
Humans
Male
Middle Aged
Neural Pathways
/ pathology
Psychiatric Status Rating Scales
Registries
White Matter
/ diagnostic imaging
Dementia caregiving
depression
diffusion tensor imaging
white matter
Journal
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
14
10
2019
revised:
11
11
2019
accepted:
28
11
2019
pubmed:
2
1
2020
medline:
16
4
2021
entrez:
2
1
2020
Statut:
ppublish
Résumé
We sought to determine whether the aspects of white matter connectivity implicated in major depression also relate to mild depressive symptoms in family dementia caregivers (dCGs). Forty-one dCGs (average age=69 years, standard deviation=6.4) underwent a 7 Tesla 64-direction (12-minute) diffusion-weighted imaging sequence. We compared the fractional anisotropy (FA) of 11 white matter features between dCGs with (n=20) and without (n=21) depressive symptoms (Patient Health Questionnaire-9 scores ≥5). Caregivers reporting depression symptoms had lower FA in tracts connecting to the posterior cingulate cortex (Cohen's d = -0.9) and connecting dorsolateral prefrontal with rostral cingulate regions (Cohen's d = -1.2). Posterior cingulate and dorsolateral prefrontal-to-rostral cingulate white matter, implicated in prior studies of major depression, appear relevant to mild depression in dCGs.
Identifiants
pubmed: 31892441
pii: S1064-7481(19)30578-0
doi: 10.1016/j.jagp.2019.11.010
pmc: PMC7170753
mid: NIHMS1062186
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
578-582Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM113243
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH112683
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056782
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111265
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063525
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118270
Pays : United States
Informations de copyright
Copyright © 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
Références
Arch Gen Psychiatry. 2012 Jul;69(7):680-9
pubmed: 22752234
Neuron. 2006 Sep 21;51(6):871-82
pubmed: 16982430
Am J Geriatr Psychiatry. 2017 Jun;25(6):582-591
pubmed: 28336265
Int Psychogeriatr. 2019 Oct 29;:1-8
pubmed: 31658928
Front Neuroanat. 2019 May 08;13:43
pubmed: 31133822
Neuropsychologia. 2013 Jan;51(1):67-78
pubmed: 23178227
Int J Geriatr Psychiatry. 2014 Dec;29(12):1173-84
pubmed: 24798480
Am J Geriatr Psychiatry. 2019 Dec;27(12):1316-1330
pubmed: 31477459
Mol Psychiatry. 2013 Sep;18(9):963-74
pubmed: 23439482
Nat Neurosci. 2009 Nov;12(11):1370-1
pubmed: 19820707
J Affect Disord. 2011 Dec;135(1-3):216-20
pubmed: 21862137
Brain. 2014 Jan;137(Pt 1):12-32
pubmed: 23869106
Am J Geriatr Psychiatry. 2015 Mar;23(3):293-303
pubmed: 24935785
J Neurosci. 2014 Jul 23;34(30):10041-54
pubmed: 25057206
Gerontologist. 1980 Dec;20(6):649-55
pubmed: 7203086
Brain Imaging Behav. 2018 Dec;12(6):1708-1719
pubmed: 29460166
Eur J Neurosci. 2016 Jan;43(2):258-69
pubmed: 26547510
PLoS One. 2012;7(11):e48107
pubmed: 23144849
Am J Geriatr Psychiatry. 2019 Oct;27(10):1046-1056
pubmed: 31133468
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941