CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.
Animals
Biomarkers, Tumor
/ analysis
Drug Resistance, Neoplasm
/ physiology
Heterografts
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ metabolism
Membrane Glycoproteins
/ metabolism
Mice
Neoplasm, Residual
/ metabolism
Neoplastic Stem Cells
/ metabolism
Protein Kinase Inhibitors
/ pharmacology
Receptors, Complement
/ metabolism
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
08
07
2019
accepted:
05
12
2019
revised:
17
11
2019
pubmed:
4
1
2020
medline:
8
10
2020
entrez:
4
1
2020
Statut:
ppublish
Résumé
The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the identification and elimination of low-level disease persistence, termed "minimal residual disease". The phenomenon of disease persistence suggests that despite targeted therapeutic approaches, BCR-ABL-independent mechanisms exist which sustain the survival of leukemic stem cells (LSCs). Although other markers of a primitive CML LSC population have been identified in the preclinical setting, only CD26 appears to offer clinical utility. Here we demonstrate consistent and selective expression of CD93 on a lin
Identifiants
pubmed: 31896780
doi: 10.1038/s41375-019-0684-5
pii: 10.1038/s41375-019-0684-5
pmc: PMC7272220
mid: EMS85133
doi:
Substances chimiques
Biomarkers, Tumor
0
Membrane Glycoproteins
0
Protein Kinase Inhibitors
0
Receptors, Complement
0
complement 1q receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1613-1625Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100626
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CAF/08/09
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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