Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.

Animals Carrier Proteins Cell Differentiation Glycoproteins / metabolism Humans Membrane Glycoproteins Mice Neutrophils / metabolism Osteoclasts / metabolism Osteoprotegerin Pancreatic Elastase Quality of Life RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear
Elastase Neutrophils Osteoclasts Osteoprotegerin

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
03 2020
Historique:
received: 21 10 2019
revised: 18 12 2019
accepted: 25 12 2019
pubmed: 4 1 2020
medline: 22 6 2021
entrez: 4 1 2020
Statut: ppublish

Résumé

Neutrophils are one of the most abundant leukocytes in the sites of lesion of inflammatory diseases such as periodontitis and rheumatoid arthritis. These diseases are accompanied by bone loss, which worsens the quality of life of the patients. However, the role of neutrophils in the inflammatory bone loss has not been fully investigated. In the present study, we found that human neutrophils enhanced osteoclast differentiation from mouse bone marrow cells co-cultured with mouse osteoblasts in the presence of active vitamin D

Identifiants

DOI: 10.1016/j.bone.2019.115216 PMID: 31899346
pubmed: 31899346
pii: S8756-3282(19)30512-5
doi: 10.1016/j.bone.2019.115216
pii:
doi:

Substances chimiques

Carrier Proteins 0
Glycoproteins 0
Membrane Glycoproteins 0
Osteoprotegerin 0
RANK Ligand 0
Receptor Activator of Nuclear Factor-kappa B 0
Receptors, Cytoplasmic and Nuclear 0
Pancreatic Elastase EC 3.4.21.36

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

115216

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest All authors declare that the research was conducted in the absence of financial interest and they have no conflict of interest.

Auteurs

Risa Sugisaki (R)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

Yoichi Miyamoto (Y)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan. Electronic address: yoichim@dent.showa-u.ac.jp.

Kentaro Yoshimura (K)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan.

Kiyohito Sasa (K)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan.

Kotaro Kaneko (K)

Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

Motohiro Tanaka (M)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan.

Masakatsu Itose (M)

Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan.

Sakie Inoue (S)

Department of Prosthodontics, Showa University School of Dentistry, Tokyo, Japan.

Kazuyoshi Baba (K)

Department of Prosthodontics, Showa University School of Dentistry, Tokyo, Japan.

Tatsuo Shirota (T)

Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan.

Daichi Chikazu (D)

Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.

Ryutaro Kamijo (R)

Department of Biochemistry, Showa University School of Dentistry, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteurs leurres aux facteurs de nécrose tumorale › Ostéoprotégérine › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Pancreatic elastase › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de RANK › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteur activateur du facteur nucléaire Kappa B › Possible involvement of elastase in enhanced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Possible involvement of elastase in enhanced...