Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives.

Acetylcholinesterase / drug effects Benzylamines / chemistry Butyrylcholinesterase / drug effects Cholinesterase Inhibitors / chemical synthesis Drug Design Electrochemical Techniques Inhibitory Concentration 50 Molecular Docking Simulation Oxazoles / chemistry Photochemical Processes Structure-Activity Relationship
Arylethenyl-oxazole benzylamine cholinesterase electrocyclization naphthoxazole synthesis

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2020
Historique:
entrez: 5 1 2020
pubmed: 5 1 2020
medline: 7 3 2020
Statut: ppublish

Résumé

The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are primary targets in attenuating the symptoms of neurodegenerative diseases. Their inhibition results in elevated concentrations of the neurotransmitter acetylcholine which supports communication among nerve cells. It was previously shown for

Identifiants

DOI: 10.1080/14756366.2019.1707197 PMID: 31899981 PMC: PMC6968547
pubmed: 31899981
doi: 10.1080/14756366.2019.1707197
pmc: PMC6968547
doi:

Substances chimiques

Benzylamines 0
Cholinesterase Inhibitors 0
Oxazoles 0
benzylamine A1O31ROR09
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

460-467

Références

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Auteurs

Ivana Šagud (I)

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.

Nikolina Maček Hrvat (N)

Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.

Ana Grgičević (A)

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.

Tena Čadež (T)

Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.

Josipa Hodak (J)

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.

Milena Dragojević (M)

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.

Kornelija Lasić (K)

TEVA, Pliva Tapi R&D, Zagreb, Croatia.

Zrinka Kovarik (Z)

Institute for Medical Research and Occupational Health, Biochemistry and Analytic Organic Chemistry Unit, Zagreb, Croatia.

Irena Škorić (I)

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Design, synthesis and cholinesterase...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Benzylamines › Design, synthesis and cholinesterase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Design, synthesis and cholinesterase...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Design, synthesis and cholinesterase...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, synthesis and cholinesterase...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Design, synthesis and cholinesterase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Design, synthesis and cholinesterase...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Design, synthesis and cholinesterase...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Design, synthesis and cholinesterase...
questionsmedicales.fr › Phénomènes chimiques › Processus photochimiques › Design, synthesis and cholinesterase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, synthesis and cholinesterase...