Crimean-Congo hemorrhagic fever virus replication imposes hyper-lipidation of MAP1LC3 in epithelial cells.
Animals
Autophagy
Autophagy-Related Protein 5
/ metabolism
Autophagy-Related Protein 7
/ metabolism
Beclin-1
/ metabolism
Chlorocebus aethiops
Epithelial Cells
/ virology
HeLa Cells
Hemorrhagic Fever Virus, Crimean-Congo
/ genetics
Hemorrhagic Fever, Crimean
/ diagnosis
Hep G2 Cells
Hepatocytes
/ virology
Humans
Lipids
/ chemistry
Microtubule-Associated Proteins
/ metabolism
Protein Biosynthesis
Sequestosome-1 Protein
/ metabolism
Vero Cells
Virus Replication
Autophagy
CCHFV
LC3 lipidation
epithelial cells
viral infection
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
7
1
2020
medline:
28
9
2021
entrez:
7
1
2020
Statut:
ppublish
Résumé
Crimean-Congo hemorrhagic fever virus (CCHFV) is a virus that causes severe liver dysfunctions and hemorrhagic fever, with high mortality rate. Here, we show that CCHFV infection caused a massive lipidation of LC3 in hepatocytes. This lipidation was not dependent on
Identifiants
pubmed: 31905032
doi: 10.1080/15548627.2019.1709765
pmc: PMC8386629
doi:
Substances chimiques
ATG5 protein, human
0
Autophagy-Related Protein 5
0
BECN1 protein, human
0
Beclin-1
0
Lipids
0
MAP1LC3A protein, human
0
Microtubule-Associated Proteins
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
ATG7 protein, human
EC 6.2.1.45
Autophagy-Related Protein 7
EC 6.2.1.45
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1858-1870Références
Antiviral Res. 2004 Dec;64(3):145-60
pubmed: 15550268
Cell Host Microbe. 2012 Mar 15;11(3):298-305
pubmed: 22423969
Cell. 2010 Aug 20;142(4):590-600
pubmed: 20723759
Cell. 2007 Dec 14;131(6):1149-63
pubmed: 18083104
Cell Death Differ. 2005 Nov;12 Suppl 2:1509-18
pubmed: 16247498
J Innate Immun. 2013;5(5):480-93
pubmed: 23391695
Sci Rep. 2019 Mar 14;9(1):4560
pubmed: 30872707
Autophagy. 2007 Jul-Aug;3(4):323-8
pubmed: 17387262
J Gen Virol. 2010 Jan;91(Pt 1):189-98
pubmed: 19812268
Curr Opin Infect Dis. 2007 Oct;20(5):495-500
pubmed: 17762783
Cell Host Microbe. 2010 Jun 25;7(6):500-8
pubmed: 20542253
J Clin Virol. 2015 Mar;64:137-43
pubmed: 25453328
Cell Mol Life Sci. 2013 Dec;70(24):4681-94
pubmed: 23800989
Microbes Infect. 2012 Feb;14(2):126-39
pubmed: 22051604
Biochim Biophys Acta. 2009 Sep;1793(9):1478-84
pubmed: 19264100
Nat Cell Biol. 2013 Jul;15(7):713-20
pubmed: 23817233
Nat Cell Biol. 2015 Mar;17(3):300-10
pubmed: 25686249
Nat Immunol. 2009 May;10(5):480-7
pubmed: 19305394
PLoS One. 2012;7(1):e29712
pubmed: 22238639
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Cell Host Microbe. 2014 Feb 12;15(2):239-47
pubmed: 24528869
PLoS Pathog. 2013;9(9):e1003599
pubmed: 24086130
Virus Res. 2014 Jan 22;179:187-203
pubmed: 24184319
Autophagy. 2010 Jan;6(1):126-37
pubmed: 20061800
Lancet Infect Dis. 2006 Apr;6(4):203-14
pubmed: 16554245
J Hepatol. 2013 Jul;59(1):98-104
pubmed: 23485523
Zoonoses Public Health. 2018 Aug;65(5):465-480
pubmed: 29676526
Autophagy. 2014 Sep;10(9):1637-51
pubmed: 25046112
Cell. 2005 Jan 28;120(2):159-62
pubmed: 15680321
J Biol Chem. 2007 Aug 17;282(33):24131-45
pubmed: 17580304
Nat Rev Immunol. 2016 Nov;16(11):661-675
pubmed: 27694913
Adv Virus Res. 2016;95:149-95
pubmed: 27112282
AIDS. 2015 Jan 28;29(3):275-86
pubmed: 25490467
Front Immunol. 2013 Jan 17;3:426
pubmed: 23335927
Cell Microbiol. 2013 Mar;15(3):368-76
pubmed: 23051682
Arch Pathol Lab Med. 1997 Aug;121(8):839-46
pubmed: 9278612
J Innate Immun. 2013;5(5):456-70
pubmed: 23652193
Antiviral Res. 2013 Oct;100(1):159-89
pubmed: 23906741
Autophagy. 2011 Dec;7(12):1434-47
pubmed: 22024753
PLoS One. 2014 Apr 15;9(4):e95197
pubmed: 24736649