Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia.
Administration, Oral
Animals
Anti-Bacterial Agents
/ administration & dosage
Brain Ischemia
/ metabolism
Case-Control Studies
Cytokines
/ metabolism
Diabetes Mellitus, Type 2
/ complications
Endotoxemia
/ drug therapy
Gastrointestinal Microbiome
/ drug effects
Gram-Negative Bacteria
/ metabolism
Immunity, Innate
/ drug effects
Infarction, Middle Cerebral Artery
/ complications
Lipopolysaccharides
/ blood
Male
Mice
Models, Animal
Neurogenic Inflammation
/ drug therapy
Polymyxin B
/ administration & dosage
Stroke
/ metabolism
Survival Rate
Toll-Like Receptor 4
/ drug effects
Gut microbiota
lipopolysaccharide
metabolic endotoxemia
stroke
type 2 diabetes
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
9
1
2020
medline:
23
3
2021
entrez:
9
1
2020
Statut:
ppublish
Résumé
Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria and a potent inflammatory stimulus for the innate immune response via toll-like receptor (TLR) 4 activation. Type 2 diabetes is associated with changes in gut microbiota and impaired intestinal barrier functions, leading to translocation of microbiota-derived LPS into the circulatory system, a condition referred to as metabolic endotoxemia. We investigated the effects of metabolic endotoxemia after experimental stroke with transient middle cerebral artery occlusion (MCAO) in a murine model of type 2 diabetes (
Identifiants
pubmed: 31910709
doi: 10.1177/0271678X19899577
pmc: PMC7820690
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cytokines
0
Lipopolysaccharides
0
TLR4 protein, human
0
Toll-Like Receptor 4
0
Polymyxin B
J2VZ07J96K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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