Resolvin D1 promotes efferocytosis in aging by limiting senescent cell-induced MerTK cleavage.
Aging
Animals
Cellular Senescence
/ drug effects
Docosahexaenoic Acids
/ pharmacology
Inflammation
/ drug therapy
Macrophages
/ drug effects
Male
Mice, Inbred C57BL
Mice, Transgenic
Neutrophils
/ metabolism
Peritonitis
/ drug therapy
Phagocytosis
/ drug effects
Receptor Protein-Tyrosine Kinases
/ metabolism
Reperfusion Injury
/ drug therapy
c-Mer Tyrosine Kinase
/ drug effects
MerTK
SASP
efferocytosis
inflammation‐resolution
resolvin
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
19
08
2019
revised:
08
10
2019
accepted:
09
10
2019
entrez:
10
1
2020
pubmed:
10
1
2020
medline:
8
7
2020
Statut:
ppublish
Résumé
Inflammation-resolution is mediated by the balance between specialized pro-resolving mediators (SPMs) like resolvin D1 (RvD1) and pro-inflammatory factors, like leukotriene B
Identifiants
pubmed: 31914705
doi: 10.1096/fj.201902126R
pmc: PMC6956736
mid: NIHMS1057805
doi:
Substances chimiques
resolvin D1
0
Docosahexaenoic Acids
25167-62-8
Mertk protein, mouse
EC 2.7.10.1
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
c-Mer Tyrosine Kinase
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-609Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL106173
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL119587
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL106173
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL141127
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM095467
Pays : United States
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM105949
Pays : International
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM095467
Pays : International
Organisme : NIGMS NIH HHS
ID : R35 GM131842
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM105949
Pays : United States
Informations de copyright
© 2019 Federation of American Societies for Experimental Biology.
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