Molecular characterization of carbapenem-resistant Klebsiella pneumoniae ST14 and ST512 causing bloodstream infections in ICU and surgery wards of a tertiary university hospital of Verona (northern Italy): co-production of KPC-3, OXA-48, and CTX-M-15 β-lactamases.
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ biosynthesis
Drug Resistance, Multiple, Bacterial
Genetic Variation
Hospitals, University
/ statistics & numerical data
Humans
Intensive Care Units
/ statistics & numerical data
Italy
Klebsiella Infections
/ blood
Klebsiella pneumoniae
/ drug effects
Microbial Sensitivity Tests
Patients' Rooms
/ statistics & numerical data
Tertiary Care Centers
/ statistics & numerical data
beta-Lactamases
/ biosynthesis
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
07
2019
revised:
02
12
2019
accepted:
11
12
2019
pubmed:
12
1
2020
medline:
2
10
2020
entrez:
12
1
2020
Statut:
ppublish
Résumé
Klebsiella pneumoniae strain is an important opportunistic pathogen that causes severe nosocomial infections. In the present study a molecular characterization of carbapenem resistant K. pneumoniae, isolated from blood samples of hospitalized patients of Verona University Hospital, was performed. The simultaneous presence of SHV-1/CTX-M-15/KPC-3 and SHV-1/CTX-M-15/OXA-48 serin-β-lactamases was ascertained in the 89% and 11% of K. pneumoniae ST512 and K. pneumoniae ST14, respectively. Molecular characterization of bla genes showed that bla
Identifiants
pubmed: 31924425
pii: S0732-8893(19)30766-7
doi: 10.1016/j.diagmicrobio.2019.114968
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
beta-lactamase CTX-M-15
EC 3.5.2.-
beta-Lactamases
EC 3.5.2.6
beta-lactamase KPC-3, Klebsiella pneumoniae
EC 3.5.2.6
oxacillinase
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114968Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest None to declare.