Cross-presentation of exogenous antigens on MHC I molecules.


Journal

Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118

Informations de publication

Date de publication:
06 2020
Historique:
received: 15 10 2019
accepted: 09 12 2019
pubmed: 14 1 2020
medline: 5 4 2022
entrez: 14 1 2020
Statut: ppublish

Résumé

In order to get recognized by CD8 T cells, most cells present peptides from endogenously expressed self or foreign proteins on MHC class I molecules. However, specialized antigen-presenting cells, such as DCs and macrophages, can present exogenous antigen on MHC-I in a process called cross-presentation. This pathway plays key roles in antimicrobial and antitumor immunity, and also immune tolerance. Recent advances have broadened our understanding of the underlying mechanisms of cross-presentation. Here, we review some of these recent advances, including the distinct pathways that result in the cross-priming of CD8 T cells and the source of the class I molecules presenting exogenous peptides.

Identifiants

pubmed: 31927332
pii: S0952-7915(19)30102-5
doi: 10.1016/j.coi.2019.12.005
pmc: PMC7343603
mid: NIHMS1569519
pii:
doi:

Substances chimiques

Histocompatibility Antigens Class I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI114495
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145932
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Auteurs

Jeff D Colbert (JD)

Department of Pathology, University of Massachusetts Medical School, United States.

Freidrich M Cruz (FM)

Department of Pathology, University of Massachusetts Medical School, United States.

Kenneth L Rock (KL)

Department of Pathology, University of Massachusetts Medical School, United States. Electronic address: kenneth.rock@umassmed.edu.

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