A chromatin scaffold for DNA damage recognition: how histone methyltransferases prime nucleosomes for repair of ultraviolet light-induced lesions.
Chromatin
/ genetics
DNA Damage
/ genetics
DNA Repair
/ genetics
Genomic Instability
/ genetics
Histone Methyltransferases
/ chemistry
Histones
/ genetics
Methylation
/ radiation effects
Nucleosomes
/ genetics
Saccharomyces cerevisiae
/ genetics
Signal Transduction
/ radiation effects
Ultraviolet Rays
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
28 02 2020
28 02 2020
Historique:
accepted:
23
12
2019
revised:
18
12
2019
received:
16
10
2019
pubmed:
14
1
2020
medline:
31
3
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
The excision of mutagenic DNA adducts by the nucleotide excision repair (NER) pathway is essential for genome stability, which is key to avoiding genetic diseases, premature aging, cancer and neurologic disorders. Due to the need to process an extraordinarily high damage density embedded in the nucleosome landscape of chromatin, NER activity provides a unique functional caliper to understand how histone modifiers modulate DNA damage responses. At least three distinct lysine methyltransferases (KMTs) targeting histones have been shown to facilitate the detection of ultraviolet (UV) light-induced DNA lesions in the difficult to access DNA wrapped around histones in nucleosomes. By methylating core histones, these KMTs generate docking sites for DNA damage recognition factors before the chromatin structure is ultimately relaxed and the offending lesions are effectively excised. In view of their function in priming nucleosomes for DNA repair, mutations of genes coding for these KMTs are expected to cause the accumulation of DNA damage promoting cancer and other chronic diseases. Research on the question of how KMTs modulate DNA repair might pave the way to the development of pharmacologic agents for novel therapeutic strategies.
Identifiants
pubmed: 31930303
pii: 5701454
doi: 10.1093/nar/gkz1229
pmc: PMC7038933
doi:
Substances chimiques
Chromatin
0
Histones
0
Nucleosomes
0
Histone Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1652-1668Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
Références
Development. 2013 Oct;140(20):4182-92
pubmed: 24004944
J Biol Chem. 2006 Jan 6;281(1):559-68
pubmed: 16267050
Nat Struct Mol Biol. 2013 Mar;20(3):259-66
pubmed: 23463310
Stem Cells. 2019 Jan;37(1):115-127
pubmed: 30270478
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
EMBO J. 2001 Apr 17;20(8):2004-14
pubmed: 11296233
Nucleic Acids Res. 1996 Jul 1;24(13):2551-9
pubmed: 8692695
Oncotarget. 2015 Feb 10;6(4):2466-82
pubmed: 25537518
J Biol Chem. 2010 Aug 20;285(34):26295-303
pubmed: 20562439
Nucleic Acids Res. 2011 Mar;39(4):1390-7
pubmed: 20972224
Genetics. 1998 Oct;150(2):613-32
pubmed: 9755194
Blood. 1999 Jul 15;94(2):724-32
pubmed: 10397739
Genes Dev. 2000 Feb 1;14(3):349-59
pubmed: 10673506
Nat Commun. 2018 Jan 17;9(1):259
pubmed: 29343685
Photochem Photobiol. 2017 Jan;93(1):166-177
pubmed: 27696486
Mol Cell. 2015 May 7;58(3):468-82
pubmed: 25921070
J Invest Dermatol. 2012 Mar;132(3 Pt 2):785-96
pubmed: 22217736
Nucleic Acids Res. 2019 Sep 19;47(16):8337-8347
pubmed: 31372632
Prog Nucleic Acid Res Mol Biol. 1999;62:227-55
pubmed: 9932456
Genetics. 1994 Aug;137(4):1027-38
pubmed: 7982557
Mol Cell Biol. 2000 Dec;20(24):9173-81
pubmed: 11094069
Chem Res Toxicol. 2017 Jun 19;30(6):1344-1354
pubmed: 28460163
Nature. 2009 Jul 9;460(7252):287-91
pubmed: 19483677
Mol Cell. 2001 Jul;8(1):213-24
pubmed: 11511374
Nat Commun. 2019 Jun 26;10(1):2803
pubmed: 31243293
Mol Cell Biol. 2007 Dec;27(24):8466-79
pubmed: 17923682
Nat Rev Mol Cell Biol. 2014 Jul;15(7):465-81
pubmed: 24954209
Nat Rev Genet. 2012 Apr 03;13(5):343-57
pubmed: 22473383
Cold Spring Harb Perspect Med. 2017 Jun 1;7(6):
pubmed: 28193767
Cell. 2011 Nov 23;147(5):1024-39
pubmed: 22118460
Nat Genet. 2008 Jul;40(7):897-903
pubmed: 18552846
J Cell Sci. 2008 Sep 1;121(Pt 17):2850-9
pubmed: 18682493
Cell. 2019 Mar 7;176(6):1490-1501.e12
pubmed: 30765112
Blood. 2010 Nov 25;116(22):4483-91
pubmed: 20798234
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6669-74
pubmed: 9618470
Nat Commun. 2014 Apr 28;5:3695
pubmed: 24770583
J Biol Chem. 2013 Jun 21;288(25):18271-82
pubmed: 23653357
J Mol Biol. 2018 Oct 26;430(22):4496-4512
pubmed: 29733857
Mol Cell. 2006 May 5;22(3):383-94
pubmed: 16678110
Mol Cell. 2012 Nov 30;48(4):491-507
pubmed: 23200123
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2215-20
pubmed: 9122174
J Biol Chem. 2011 Mar 11;286(10):8369-74
pubmed: 21239497
Int J Biochem. 1989;21(11):1235-40
pubmed: 2482203
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6758-6763
pubmed: 28607063
EMBO J. 1997 Oct 15;16(20):6281-9
pubmed: 9321407
Nat Commun. 2019 Jun 28;10(1):2885
pubmed: 31253769
J Immunol. 2013 Jan 15;190(2):756-63
pubmed: 23241889
Mol Cell Biol. 2005 Oct;25(19):8430-43
pubmed: 16166626
Annu Rev Genet. 2009;43:559-99
pubmed: 19886812
J Radiat Res. 2011;52(2):115-25
pubmed: 21436607
PLoS Genet. 2018 Nov 28;14(11):e1007823
pubmed: 30485262
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6752-6757
pubmed: 28607059
J Biol Chem. 2014 Sep 26;289(39):27278-89
pubmed: 25118285
Biochemistry. 1993 Oct 12;32(40):10527-31
pubmed: 8399198
Blood. 2011 May 5;117(18):4759-68
pubmed: 21398221
J Biol Chem. 2006 May 12;281(19):13404-11
pubmed: 16527807
Biochim Biophys Acta. 2011 Jan;1815(1):75-89
pubmed: 20951770
Photochem Photobiol. 2011 Jan-Feb;87(1):109-16
pubmed: 21091484
Biochem Biophys Res Commun. 2016 Feb 26;471(1):117-22
pubmed: 26837048
Sci Rep. 2016 May 27;6:26597
pubmed: 27229316
Biomolecules. 2018 Feb 27;8(1):
pubmed: 29495487
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2588-93
pubmed: 16473935
EMBO J. 2003 Oct 1;22(19):5163-74
pubmed: 14517254
J Comput Biol. 2019 Oct;26(10):1168-1176
pubmed: 31246501
Eur J Med Genet. 2019 Jan;62(1):55-60
pubmed: 29753921
Mol Cell. 2018 Dec 6;72(5):888-901.e7
pubmed: 30344095
J Clin Invest. 2015 May;125(5):2007-20
pubmed: 25866973
J Biol Chem. 2000 Mar 31;275(13):9870-5
pubmed: 10734143
Nat Commun. 2017 Nov 6;8(1):1333
pubmed: 29109511
EMBO J. 2009 Aug 19;28(16):2387-99
pubmed: 19609301
J Biol Chem. 2002 Sep 20;277(38):34655-7
pubmed: 12167634
Nat Commun. 2018 Jul 6;9(1):2626
pubmed: 29980679
J Cell Biol. 1998 Nov 2;143(3):563-75
pubmed: 9813080
Nucleic Acids Res. 2017 Jun 2;45(10):5901-5912
pubmed: 28402505
PLoS Biol. 2007 Apr;5(4):e79
pubmed: 17355181
J Biol Chem. 1995 Feb 10;270(6):2415-8
pubmed: 7852297
Cell. 2005 May 6;121(3):387-400
pubmed: 15882621
Sci Rep. 2017 Apr 04;7:45401
pubmed: 28374742
Structure. 2019 May 7;27(5):837-845.e3
pubmed: 30827843
Mol Cell Biol. 2005 Jul;25(13):5664-74
pubmed: 15964821
J Cell Biol. 2012 Apr 16;197(2):267-81
pubmed: 22492724
J Cell Biol. 2012 Oct 15;199(2):235-49
pubmed: 23045548
Am J Hum Genet. 2018 Jan 4;102(1):175-187
pubmed: 29276005
J Cell Biol. 2009 May 18;185(4):577-86
pubmed: 19451271
EMBO J. 2009 Apr 22;28(8):1111-20
pubmed: 19279666
EMBO J. 2005 Nov 16;24(22):3952-62
pubmed: 16252008
Genome Res. 2014 Jun;24(6):896-905
pubmed: 24714810
Mol Cell. 2009 Nov 25;36(4):642-53
pubmed: 19941824
Photochem Photobiol. 1990 Apr;51(4):411-7
pubmed: 2160660
J Biol Chem. 2013 Oct 25;288(43):30832-42
pubmed: 24019522
J Biol Chem. 2009 Oct 30;284(44):30424-32
pubmed: 19740755
Photochem Photobiol. 2019 Jan;95(1):140-153
pubmed: 30565713
Nat Genet. 2016 May;48(5):500-9
pubmed: 27064257
Mutat Res. 2009 Jul-Aug;682(1):13-20
pubmed: 19167517
Nature. 2011 Feb 3;470(7332):124-8
pubmed: 21293379
Mol Cell. 2013 Aug 22;51(4):469-79
pubmed: 23973375
EMBO J. 2001 Jul 2;20(13):3554-64
pubmed: 11432842
PLoS Genet. 2013 Nov;9(11):e1003897
pubmed: 24244179
Hum Mol Genet. 1998 Jul;7(7):1071-82
pubmed: 9618163
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80
pubmed: 20937877
Genetics. 2006 Aug;173(4):1951-68
pubmed: 16783014
DNA Repair (Amst). 2011 Jul 15;10(7):772-80
pubmed: 21680258
Elife. 2014 Apr 15;3:e02042
pubmed: 24737864
Cell. 2006 Nov 3;127(3):481-93
pubmed: 17081972
Arch Toxicol. 2016 Nov;90(11):2583-2594
pubmed: 27549370
Mol Cell Biol. 2008 Dec;28(23):7225-35
pubmed: 18809580
Cell Chem Biol. 2016 Sep 22;23(9):1049-1055
pubmed: 27569752
Mol Cell Biol. 2000 Feb;20(4):1206-18
pubmed: 10648606
Mol Cell. 2013 Jan 10;49(1):80-93
pubmed: 23159737
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6847-E6856
pubmed: 28760956
Nucleic Acids Res. 2019 Jul 9;47(12):6015-6028
pubmed: 31106376
Chromosoma. 2016 Sep;125(4):593-605
pubmed: 26728620
Nucleic Acids Res. 2014 Jan;42(2):893-905
pubmed: 24137003
Curr Biol. 2013 Feb 4;23(3):204-12
pubmed: 23352696
Essays Biochem. 2019 Apr 23;63(1):97-107
pubmed: 30940741
Cold Spring Harb Perspect Biol. 2013 Oct 01;5(10):a012609
pubmed: 24086042
Cell. 1995 Mar 24;80(6):859-68
pubmed: 7697716
Blood. 1998 Nov 1;92(9):3025-34
pubmed: 9787135
J Biol Chem. 2010 Oct 8;285(41):31370-9
pubmed: 20675387
Eur J Biochem. 1995 Mar 15;228(3):849-54
pubmed: 7737185
Clin Cancer Res. 2011 May 1;17(9):2919-33
pubmed: 21385930
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):424-8
pubmed: 9892649
J Mol Biol. 1998 Oct 9;282(5):1013-32
pubmed: 9753551
DNA Repair (Amst). 2007 Mar 1;6(3):383-95
pubmed: 17267293
J Cell Biol. 2009 Aug 10;186(3):371-7
pubmed: 19667127
J Cell Sci. 2009 Jan 1;122(Pt 1):83-91
pubmed: 19066286
PLoS Genet. 2008 Sep 12;4(9):e1000190
pubmed: 18787701
Chem Biol. 2005 Aug;12(8):913-22
pubmed: 16125103
N Engl J Med. 2009 Oct 8;361(15):1475-85
pubmed: 19812404
EMBO J. 2013 Aug 28;32(17):2392-406
pubmed: 23921552
DNA Repair (Amst). 2018 May;65:73-78
pubmed: 29631253
Cell. 2013 Sep 26;155(1):94-106
pubmed: 24074863
Int J Mol Sci. 2012;13(9):11954-73
pubmed: 23109894
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9057-62
pubmed: 27457959
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2124-33
pubmed: 27036006
Photodermatol Photoimmunol Photomed. 2002 Jun;18(3):109-16
pubmed: 12207672
J Biol Chem. 1991 Nov 25;266(33):22472-8
pubmed: 1939267
J Cell Biol. 2011 Apr 18;193(2):307-18
pubmed: 21482720
Sci Rep. 2015 Jun 04;5:10984
pubmed: 26042670
Nat Struct Mol Biol. 2006 Oct;13(10):902-7
pubmed: 17013386
Cold Spring Harb Perspect Med. 2016 Nov 1;6(11):
pubmed: 27580749
Nucleic Acids Res. 1998 Aug 15;26(16):3845-53
pubmed: 9685504
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003210
J Biol Chem. 2012 Apr 6;287(15):12036-49
pubmed: 22334663
Photochem Photobiol Sci. 2018 Dec 5;17(12):1816-1841
pubmed: 29405222
Anticancer Res. 2018 Feb;38(2):1159-1164
pubmed: 29374753
Cell Mol Life Sci. 2015 Dec;72(23):4577-92
pubmed: 26305020
DNA Repair (Amst). 2005 Mar 2;4(3):389-95
pubmed: 15661662
Cell. 1996 Sep 20;86(6):887-96
pubmed: 8808624
Genes Dev. 2019 Jun 1;33(11-12):620-625
pubmed: 30923167
Cell Cycle. 2009 Dec;8(23):3953-9
pubmed: 19901545
DNA Repair (Amst). 2016 Aug;44:110-117
pubmed: 27264556
EMBO J. 1997 Feb 3;16(3):625-38
pubmed: 9034344
Genetics. 1989 Mar;121(3):517-25
pubmed: 2497049
Genes Dev. 2011 Jul 1;25(13):1345-58
pubmed: 21724828
Cell. 2003 May 2;113(3):357-67
pubmed: 12732143
Genes Cells. 2017 Mar;22(3):310-327
pubmed: 28233440
PLoS Genet. 2013;9(7):e1003611
pubmed: 23861670
J Biol Chem. 2003 Nov 21;278(47):46906-10
pubmed: 12944386
J Biol Chem. 2011 May 20;286(20):17530-5
pubmed: 21460225
DNA Repair (Amst). 2015 Dec;36:114-121
pubmed: 26429064
Nucleic Acids Res. 2009 Apr;37(5):1690-700
pubmed: 19155276
Nat Commun. 2015 Jul 07;6:7499
pubmed: 26151477
Onco Targets Ther. 2017 Dec 28;11:131-155
pubmed: 29343972
Nature. 2007 Oct 4;449(7162):570-5
pubmed: 17882165
Nature. 2008 Jun 5;453(7196):812-6
pubmed: 18449190
Genes Dev. 2008 Aug 1;22(15):2048-61
pubmed: 18676810
J Biol Chem. 2001 Dec 21;276(51):48175-82
pubmed: 11673459
Biochem Biophys Res Commun. 2011 Jan 28;404(4):1016-22
pubmed: 21187070
EMBO J. 2009 Oct 7;28(19):2971-80
pubmed: 19713942
Nature. 2004 Nov 18;432(7015):406-11
pubmed: 15525939
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7284-9
pubmed: 10860993
Nature. 2014 May 1;509(7498):91-5
pubmed: 24670651
Mol Cell Biol. 2008 Apr;28(8):2825-39
pubmed: 18285465
Biochem Biophys Res Commun. 2010 Sep 3;399(4):512-7
pubmed: 20678485
Biophys Rep. 2018;4(4):170-177
pubmed: 30310854
Mol Cell. 2008 Jul 11;31(1):9-20
pubmed: 18614043
Cell. 2008 Dec 26;135(7):1213-23
pubmed: 19109893
J Cell Biol. 2012 Mar 19;196(6):681-8
pubmed: 22431748
J Cell Sci. 1997 May;110 ( Pt 10):1159-68
pubmed: 9191040
Nat Struct Mol Biol. 2019 Jan;26(1):3-13
pubmed: 30532059
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13765-70
pubmed: 16954188
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3664-8
pubmed: 1314396
J Biol Chem. 1996 Mar 22;271(12):7177-86
pubmed: 8636155
Nucleic Acids Res. 2008 Mar;36(5):1713-22
pubmed: 18263614
Nature. 2019 Jul;571(7763):79-84
pubmed: 31142837
Cell. 2004 Nov 24;119(5):603-14
pubmed: 15550243
J Biol Chem. 2005 Mar 18;280(11):9879-86
pubmed: 15632126
Structure. 2019 May 7;27(5):846-852.e3
pubmed: 30827841
DNA Repair (Amst). 2018 Nov;71:33-42
pubmed: 30174301
PLoS One. 2012;7(11):e49211
pubmed: 23209566
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4238-41
pubmed: 279912
J Biol Chem. 1990 Apr 5;265(10):5353-6
pubmed: 2318816
Cell. 2007 Feb 23;128(4):721-33
pubmed: 17320509
Mol Cell. 2016 Oct 6;64(1):65-78
pubmed: 27642047
EMBO Rep. 2004 Apr;5(4):373-7
pubmed: 15031712
J Cell Biol. 2013 Jun 10;201(6):797-807
pubmed: 23751493
Genes Dev. 2003 Jul 1;17(13):1630-45
pubmed: 12815074
Biol Reprod. 2015 Nov;93(5):121
pubmed: 26333994
Mol Cell. 2019 Jan 3;73(1):73-83.e6
pubmed: 30415948
EMBO J. 2001 Jun 15;20(12):3187-96
pubmed: 11406595
EMBO J. 2002 Sep 2;21(17):4719-29
pubmed: 12198174
Trends Genet. 2005 Mar;21(3):188-95
pubmed: 15734578
Insect Biochem Mol Biol. 2014 Dec;55:9-18
pubmed: 25308962
FEBS Lett. 2009 Jun 18;583(12):1880-6
pubmed: 19481544
Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17545-50
pubmed: 20876134
Mol Cell Biol. 2009 Dec;29(23):6206-19
pubmed: 19805520
Chem Rev. 2015 Mar 25;115(6):2255-73
pubmed: 25495456
PLoS Biol. 2011 Oct;9(10):e1001183
pubmed: 22039351
Nat Rev Mol Cell Biol. 2012 Jan 23;13(2):115-26
pubmed: 22266761
Elife. 2014 Apr 29;3:e02407
pubmed: 24843027
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6644-8
pubmed: 3477794
Mutat Res. 2001 Jul 12;486(2):89-97
pubmed: 11425514
Trends Biochem Sci. 2018 May;43(5):327-341
pubmed: 29699641
DNA Repair (Amst). 2011 Feb 7;10(2):119-25
pubmed: 21130713
Biochim Biophys Acta. 2015 Sep;1850(9):1842-8
pubmed: 26002201
EMBO Rep. 2002 Apr;3(4):329-34
pubmed: 11897662
Science. 2003 Jan 31;299(5607):721-5
pubmed: 12560555
Mol Cell. 2010 Mar 12;37(5):714-27
pubmed: 20227374
Nucleic Acids Res. 2002 Jun 1;30(11):2588-98
pubmed: 12034848
Mol Cell. 2007 Jul 20;27(2):311-23
pubmed: 17643379
J Biol Chem. 2000 Aug 4;275(31):23729-35
pubmed: 10821833
Curr Opin Struct Biol. 2019 Jun;56:46-55
pubmed: 30529788
J Cell Biol. 2018 Feb 5;217(2):527-540
pubmed: 29233865
Mol Cell. 2015 Sep 17;59(6):1025-34
pubmed: 26384665
Gene. 2007 Aug 1;397(1-2):161-8
pubmed: 17544230
Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17274-9
pubmed: 20855601
EMBO J. 2017 Nov 15;36(22):3372-3386
pubmed: 29018037
Mol Cell. 1998 Aug;2(2):223-32
pubmed: 9734359