Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
28
08
2019
revised:
20
11
2019
accepted:
02
12
2019
pubmed:
16
1
2020
medline:
22
8
2020
entrez:
16
1
2020
Statut:
ppublish
Résumé
There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as potential biomarker. Plasma GFAP and neurofilament light chain (NfL) concentration were measured in 469 individuals enrolled in the Genetic FTD Initiative: 114 Plasma GFAP concentration was significantly increased in symptomatic Raised GFAP concentrations appear to be unique to
Sections du résumé
BACKGROUND
There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as potential biomarker.
METHODS
Plasma GFAP and neurofilament light chain (NfL) concentration were measured in 469 individuals enrolled in the Genetic FTD Initiative: 114
RESULTS
Plasma GFAP concentration was significantly increased in symptomatic
CONCLUSIONS
Raised GFAP concentrations appear to be unique to
Identifiants
pubmed: 31937580
pii: jnnp-2019-321954
doi: 10.1136/jnnp-2019-321954
doi:
Substances chimiques
Biomarkers
0
C9orf72 Protein
0
C9orf72 protein, human
0
GRN protein, human
0
Glial Fibrillary Acidic Protein
0
MAPT protein, human
0
Neurofilament Proteins
0
Progranulins
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
263-270Subventions
Organisme : Medical Research Council
ID : MC_U123160651
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00024/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008525/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M023664/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K010395/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M018288/1
Pays : United Kingdom
Investigateurs
Martin N Rossor
(MN)
Jason D Warren
(JD)
Nick C Fox
(NC)
Rita Guerreiro
(R)
Jose Bras
(J)
Jennifer Nicholas
(J)
Simon Mead
(S)
Lize Jiskoot
(L)
Lieke Meeter
(L)
Jessica Panman
(J)
Janne Papma
(J)
Rick van Minkelen
(RV)
Yolanda Pijnenburg
(Y)
Myriam Barandiaran
(M)
Begoña Indakoetxea
(B)
Alazne Gabilondo
(A)
Mikel Tainta
(M)
Maria de Arriba
(M)
Ana Gorostidi
(A)
Miren Zulaica
(M)
Jorge Villanua
(J)
Zigor Diaz
(Z)
Sergi Borrego-Ecija
(S)
Jaume Olives
(J)
Albert Lladó
(A)
Mircea Balasa
(M)
Anna Antonell
(A)
Nuria Bargallo
(N)
Enrico Premi
(E)
Maura Cosseddu
(M)
Stefano Gazzina
(S)
Alessandro Padovani
(A)
Roberto Gasparotti
(R)
Silvana Archetti
(S)
Sandra Black
(S)
Sara Mitchell
(S)
Ekaterina Rogaeva
(E)
Morris Freedman
(M)
Ron Keren
(R)
David Tang-Wai
(D)
Linn Öijerstedt
(L)
Christin Andersson
(C)
Vesna Jelic
(V)
Hakan Thonberg
(H)
Andrea Arighi
(A)
Chiara Fenoglio
(C)
Elio Scarpini
(E)
Giorgio Fumagalli
(G)
Thomas Cope
(T)
Carolyn Timberlake
(C)
Timothy Rittman
(T)
Christen Shoesmith
(C)
Robart Bartha
(R)
Rosa Rademakers
(R)
Carlo Wilke
(C)
Hans-Otto Karnarth
(HO)
Benjamin Bender
(B)
Rose Bruffaerts
(R)
Philip Vandamme
(P)
Mathieu Vandenbulcke
(M)
Catarina B Ferreira
(CB)
Gabriel Miltenberger
(G)
Carolina Maruta
(C)
Ana Verdelho
(A)
Sónia Afonso
(S)
Ricardo Taipa
(R)
Paola Caroppo
(P)
Giuseppe Di Fede
(GD)
Giorgio Giaccone
(G)
Sara Prioni
(S)
Veronica Redaelli
(V)
Giacomina Rossi
(G)
Pietro Tiraboschi
(P)
Diana Duro
(D)
Maria Rosario Almeida
(MR)
Miguel Castelo-Branco
(M)
Maria João Leitão
(MJ)
Miguel Tabuas-Pereira
(M)
Beatriz Santiago
(B)
Serge Gauthier
(S)
Pedro Rosa-Neto
(P)
Michele Veldsman
(M)
Toby Flanagan
(T)
Catharina Prix
(C)
Tobias Hoegen
(T)
Elisabeth Wlasich
(E)
Sandra Loosli
(S)
Sonja Schonecker
(S)
Elisa Semler
(E)
Sarah Anderl-Straub
(S)
Luisa Benussi
(L)
Giuliano Binetti
(G)
Roberta Ghidoni
(R)
Michela Pievani
(M)
Gemma Lombardi
(G)
Benedetta Nacmias
(B)
Camilla Ferrari
(C)
Valentina Bessi
(V)
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.