A Combinatorial Strategy for Targeting
Animals
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Apoptosis
Cell Line, Tumor
Cell Proliferation
Drug Evaluation, Preclinical
/ methods
Drug Synergism
High-Throughput Screening Assays
/ methods
Humans
Imidazoles
/ administration & dosage
Indoles
/ administration & dosage
Mice
Mice, Inbred NOD
Mutation
Protein-Tyrosine Kinases
/ antagonists & inhibitors
Proto-Oncogene Proteins B-raf
/ antagonists & inhibitors
Pyridazines
/ administration & dosage
Sulfonamides
/ administration & dosage
Thyroid Neoplasms
/ drug therapy
Xenograft Model Antitumor Assays
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
15
05
2019
revised:
03
09
2019
accepted:
10
01
2020
pubmed:
16
1
2020
medline:
28
1
2021
entrez:
16
1
2020
Statut:
ppublish
Résumé
Most aggressive thyroid cancers are commonly associated with a The combined drug activity was analyzed to predict any synergistic effect using high-throughput screening (HTS) of active drugs. We performed follow-up The MTKI ponatinib and the BRAF inhibitor PLX4720 showed synergistic activity by HTS. This combination significantly inhibited proliferation, colony formation, invasion, and migration in Combination treatment with ponatinib and PLX4720 exhibited significant synergistic anticancer activity in preclinical models of
Identifiants
pubmed: 31937621
pii: 1078-0432.CCR-19-1606
doi: 10.1158/1078-0432.CCR-19-1606
pmc: PMC8606228
mid: NIHMS1550098
doi:
Substances chimiques
Imidazoles
0
Indoles
0
PLX 4720
0
Pyridazines
0
Sulfonamides
0
ponatinib
4340891KFS
Protein-Tyrosine Kinases
EC 2.7.10.1
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2022-2036Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011286
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA TR000108
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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