Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier.
mesoporous silica nanoparticles
pH responsive polymer
polymer brushes
surface-initiated atom transfer radical polymerization
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
03 Jan 2020
03 Jan 2020
Historique:
received:
29
11
2019
revised:
29
12
2019
accepted:
30
12
2019
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
8
10
2020
Statut:
epublish
Résumé
This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.
Identifiants
pubmed: 31947738
pii: molecules25010195
doi: 10.3390/molecules25010195
pmc: PMC6983194
pii:
doi:
Substances chimiques
Drug Carriers
0
Methacrylates
0
polyethylene glycol methacrylate
0
Polyethylene Glycols
3WJQ0SDW1A
Silicon Dioxide
7631-86-9
Doxycycline
N12000U13O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Langmuir. 2014 Feb 11;30(5):1391-400
pubmed: 24417283
Langmuir. 2019 Jun 18;35(24):7589-7602
pubmed: 30365897
Chem Soc Rev. 2013 May 7;42(9):3862-75
pubmed: 23403864
Adv Drug Deliv Rev. 2006 Dec 30;58(15):1655-70
pubmed: 17125884
J Colloid Interface Sci. 2019 Jan 1;533:604-611
pubmed: 30193147
Chem Rev. 2001 Dec;101(12):3661-88
pubmed: 11740918
Langmuir. 2009 Apr 21;25(8):4774-9
pubmed: 19243153
Small. 2010 Aug 16;6(16):1794-805
pubmed: 20623530
Chem Rev. 2001 Sep;101(9):2921-90
pubmed: 11749397
Adv Mater. 2012 Mar 22;24(12):1504-34
pubmed: 22378538
J Colloid Interface Sci. 2019 Apr 15;542:243-252
pubmed: 30763891
Nature. 2003 Jan 23;421(6921):350-3
pubmed: 12540896
Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4184-4188
pubmed: 30701642
Langmuir. 2004 May 11;20(10):4064-75
pubmed: 15969399
J Funct Biomater. 2019 Jul 31;10(3):null
pubmed: 31370252
Langmuir. 2011 Mar 15;27(6):3095-9
pubmed: 21314163