The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.
Aged
CD3 Complex
/ metabolism
Carcinoma, Pancreatic Ductal
/ diagnostic imaging
Cell Line, Tumor
Diffusion Magnetic Resonance Imaging
Female
Humans
Immunohistochemistry
Interleukin-10 Receptor beta Subunit
/ metabolism
Interleukins
/ metabolism
Male
Middle Aged
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Pancreatic Neoplasms
/ diagnostic imaging
Prognosis
Receptors, Interleukin
/ metabolism
STAT3 Transcription Factor
/ metabolism
Th17 Cells
/ cytology
Tumor Microenvironment
ADC
DW-MRI
IL21
IL26
pancreatic cancer
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Jan 2020
05 Jan 2020
Historique:
received:
16
12
2019
revised:
02
01
2020
accepted:
03
01
2020
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Diffusion-weighted magnetic resonance imaging (DW-MRI) is a diagnostic tool that is increasingly used for the detection and characterization of focal masses in the abdomen, among these, pancreatic ductal adenocarcinoma (PDAC). DW-MRI reflects the microarchitecture of the tissue, and changes in diffusion, which are reflected by changes in the apparent diffusion coefficient (ADC), are mainly attributed to variations in cellular density, glandular formation, and fibrosis. When analyzing the T cell infiltrates, we found an association of a tumor-promoting subpopulation, characterized by the expression of interleukin (IL) 21 and IL26, with high ADC values. Moreover, the presence of IL21
Identifiants
pubmed: 31948053
pii: ijms21010346
doi: 10.3390/ijms21010346
pmc: PMC6982276
pii:
doi:
Substances chimiques
CD3 Complex
0
IL10RB protein, human
0
IL26 protein, human
0
Interleukin-10 Receptor beta Subunit
0
Interleukins
0
Receptors, Interleukin
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
interleukin-20 receptor
0
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GA1818/2-1
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