Cardiovascular magnetic resonance feature tracking in pigs: a reproducibility and sample size calculation study.
Adrenergic beta-1 Receptor Agonists
/ pharmacology
Anesthesia, General
Animals
Calcium Channel Blockers
/ pharmacology
Dobutamine
/ pharmacology
Female
Heart Ventricles
/ diagnostic imaging
Magnetic Resonance Imaging, Cine
Models, Animal
Myocardial Contraction
/ drug effects
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Sample Size
Sus scrofa
Ventricular Function, Left
/ drug effects
Verapamil
/ pharmacology
Cardiovascular magnetic resonance
Feature tracking
Left ventricular strain
Porcine model
Reproducibility
Sample size
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
01
11
2019
accepted:
02
01
2020
pubmed:
18
1
2020
medline:
7
7
2020
entrez:
18
1
2020
Statut:
ppublish
Résumé
Cardiovascular magnetic resonance feature tracking (CMR-FT) is a novel technique for non-invasive assessment of myocardial motion and deformation. Although CMR-FT is standardized in humans, literature on comparative analysis from animal models is scarce. In this study, we measured the reproducibility of global strain under various inotropic states and the sample size needed to test its relative changes in pigs. Ten anesthetized healthy Landrace pigs were investigated. After baseline (BL), two further steps were performed: (I) dobutamine-induced hyper-contractility (Dob) and (II) verapamil-induced hypocontractility (Ver). Global longitudinal (GLS), circumferential (GCS) and radial strain (GRS) were assessed. This study shows a good to excellent inter- and intra-observer reproducibility of CMR-FT in pigs under various inotropic states. The highest inter-observer reproducibility was observed for GLS at both BL (ICC 0.88) and Ver (ICC 0.79). According to the sample size calculation for GLS, a small number of animals could be used for future trials.
Identifiants
pubmed: 31950298
doi: 10.1007/s10554-020-01767-y
pii: 10.1007/s10554-020-01767-y
pmc: PMC7125242
doi:
Substances chimiques
Adrenergic beta-1 Receptor Agonists
0
Calcium Channel Blockers
0
Dobutamine
3S12J47372
Verapamil
CJ0O37KU29
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
703-712Subventions
Organisme : Deutsches Zentrum für Herz-Kreislaufforschung
ID : 81X2100305
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