Recently Approved and Upcoming Treatments for Narcolepsy.


Journal

CNS drugs
ISSN: 1179-1934
Titre abrégé: CNS Drugs
Pays: New Zealand
ID NLM: 9431220

Informations de publication

Date de publication:
01 2020
Historique:
pubmed: 19 1 2020
medline: 10 6 2021
entrez: 19 1 2020
Statut: ppublish

Résumé

Narcolepsy is a chronic, disabling neurologic disorder characterised by excessive daytime sleepiness (EDS) and, in up to 60% of patients, cataplexy. Treatments for narcolepsy are aimed at improving wakefulness (e.g. modafinil, armodafinil, stimulants), reducing cataplexy attacks (e.g. sodium oxybate, venlafaxine), and treating the symptoms of disturbed nocturnal sleep, sleep paralysis and sleep-related hallucinations (e.g. sodium oxybate). In general, medications that increase the release, or inhibit the reuptake, of norepinephrine or dopamine have wake-promoting effects and are useful in managing EDS, whereas medications that inhibit serotonin or norepinephrine reuptake have anticataplectic effects. Modulation of γ-aminobutyric acid B (GABA

Identifiants

pubmed: 31953791
doi: 10.1007/s40263-019-00689-1
pii: 10.1007/s40263-019-00689-1
pmc: PMC6982634
doi:

Substances chimiques

Central Nervous System Stimulants 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-27

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Auteurs

Michael J Thorpy (MJ)

Sleep-Wake Disorders Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467-2509, USA. michael.thorpy@einstein.yu.edu.

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Classifications MeSH