Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature.
Apolipoproteins M
/ blood
Cells, Cultured
Endothelium, Vascular
/ metabolism
Female
Fetal Blood
/ metabolism
Humans
Lipoproteins, HDL
/ blood
Lysophospholipids
/ blood
MAP Kinase Signaling System
Placenta
/ blood supply
Pregnancy
Sphingosine
/ analogs & derivatives
Type C Phospholipases
/ metabolism
Bioactive lipids
High-density lipoprotein
Human placenta
Placental vascular endothelium
Pregnancy
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
04
11
2019
revised:
08
01
2020
accepted:
11
01
2020
pubmed:
19
1
2020
medline:
16
7
2020
entrez:
19
1
2020
Statut:
ppublish
Résumé
Perinatal and long-term offspring morbidities are strongly dependent on the preservation of placental vascular homeostasis during pregnancy. In adults, the HDL-apoM-S1P complex protects the endothelium and maintains vascular integrity. However, the metabolism and biology of cord blood-derived HDLs (referred to as neonatal HDL, nHDL) strikingly differ from those in adults. Here, we investigate the role of neonatal HDLs in the regulation of placental vascular function. We show that nHDL is a major carrier of sphingosine-1-phosphate (S1P), which is anchored to the particle through apoM (r
Identifiants
pubmed: 31954174
pii: S1388-1981(20)30024-X
doi: 10.1016/j.bbalip.2020.158632
pii:
doi:
Substances chimiques
APOM protein, human
0
Apolipoproteins M
0
Lipoproteins, HDL
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Type C Phospholipases
EC 3.1.4.-
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158632Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.