Harnessing ecological and evolutionary principles to guide the design of microbial production consortia.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
02
09
2019
revised:
27
11
2019
accepted:
13
12
2019
pubmed:
19
1
2020
medline:
24
10
2020
entrez:
19
1
2020
Statut:
ppublish
Résumé
Bacteria are widely used for commercially producing biomolecules. However, attempts to rationally design production strains and optimize cultivation conditions are frequently counteracted by the emergence of mutants with reduced production characteristics that decrease overall process yield. The reason why these mutants arise is likely because of a mismatch between the ecological conditions under which bacteria evolved in nature and the situation they experience in an industrial setting. Thus, there is a great potential for improving biotechnological production processes by implementing eco-evolutionary knowledge. However, this is often limited by a lack of effective communication between process engineers and microbial ecologists/evolutionary biologists. Here, we highlight recent findings in the field of microbial ecology and evolution and suggest implementation of this knowledge can significantly enhance microbial bioproduction.
Identifiants
pubmed: 31954367
pii: S0958-1669(19)30150-8
doi: 10.1016/j.copbio.2019.12.012
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-238Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.