Plasma homocysteine after laparoscopic Roux-en-Y gastric bypass increases in the early postoperative phase but decreases in the long-term follow-up. A retrospective analysis.
Bariatric surgery
Folate
Gastric bypass
Homocysteine
Obesity
Vitamin B12
Journal
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
ISSN: 1878-7533
Titre abrégé: Surg Obes Relat Dis
Pays: United States
ID NLM: 101233161
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
21
05
2019
revised:
03
11
2019
accepted:
24
11
2019
pubmed:
22
1
2020
medline:
28
4
2021
entrez:
22
1
2020
Statut:
ppublish
Résumé
Homocysteine is an important independent risk factor for predicting cardiovascular disease (CVD). However, changes in the homocysteine levels after bariatric surgery remain controversial. Modeling differences in homocysteine after bariatric surgery. University Hospital, Austria. Seven hundred eight consecutive bariatric surgery patients (78% female, 22% male, mean body mass index 41 kg/m Hyperhomocysteinemia was present in 11.8% preoperatively (normal range: <15 μmol/L). The median plasma homocysteine level was 10.4 preoperatively, 12.1 at 3, 11.2 at 6, 10.0 at 9, 9.8 at 12, 8.9 at 18, 8.7 at 24, 8.6 at 36, 9.1 at 48, 9.8 at 60, and 10.0 μmol/L at 72 months postoperatively. After subdividing the study population in morbidly obese (n = 509, body mass index 40-50 kg/m Laparoscopic Roux-en-Y gastric bypass leads to increased homocysteine levels in the early postoperative period. However, there was no relationship between increased homocysteine levels and CVD event onset.
Sections du résumé
BACKGROUND
BACKGROUND
Homocysteine is an important independent risk factor for predicting cardiovascular disease (CVD). However, changes in the homocysteine levels after bariatric surgery remain controversial.
OBJECTIVES
OBJECTIVE
Modeling differences in homocysteine after bariatric surgery.
SETTING
METHODS
University Hospital, Austria.
METHODS
METHODS
Seven hundred eight consecutive bariatric surgery patients (78% female, 22% male, mean body mass index 41 kg/m
RESULTS
RESULTS
Hyperhomocysteinemia was present in 11.8% preoperatively (normal range: <15 μmol/L). The median plasma homocysteine level was 10.4 preoperatively, 12.1 at 3, 11.2 at 6, 10.0 at 9, 9.8 at 12, 8.9 at 18, 8.7 at 24, 8.6 at 36, 9.1 at 48, 9.8 at 60, and 10.0 μmol/L at 72 months postoperatively. After subdividing the study population in morbidly obese (n = 509, body mass index 40-50 kg/m
CONCLUSION
CONCLUSIONS
Laparoscopic Roux-en-Y gastric bypass leads to increased homocysteine levels in the early postoperative period. However, there was no relationship between increased homocysteine levels and CVD event onset.
Identifiants
pubmed: 31959564
pii: S1550-7289(19)31123-2
doi: 10.1016/j.soard.2019.11.021
pii:
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
372-380Informations de copyright
Copyright © 2020. Published by Elsevier Inc.