HOPS recognizes each SNARE, assembling ternary
HOPS
S. cerevisiae
SNARE
biochemistry
chemical biology
membrane fusion
yeast vacuoles
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
21 01 2020
21 01 2020
Historique:
received:
13
11
2019
accepted:
19
01
2020
pubmed:
22
1
2020
medline:
24
4
2021
entrez:
22
1
2020
Statut:
epublish
Résumé
Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS. A HOPS SM-family subunit binds the R- and Qa-SNAREs. We now report that HOPS binds each of the four SNAREs. HOPS catalyzes fusion when the Q-SNAREs are not pre-assembled, ushering them into a functional complex. Co-incubation of HOPS, proteoliposomes bearing R-SNARE, and proteoliposomes with any two Q-SNAREs yields a rapid-fusion complex with 3 SNAREs in a
Identifiants
pubmed: 31961324
doi: 10.7554/eLife.53559
pii: 53559
pmc: PMC6994237
doi:
pii:
Substances chimiques
R-SNARE Proteins
0
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118037
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft
ID : HA 7730/2-1
Organisme : NIH HHS
ID : R35GM118037
Pays : United States
Informations de copyright
© 2020, Song et al.
Déclaration de conflit d'intérêts
HS, AO, ML, MH, WW No competing interests declared
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