Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Colorectal Neoplasms
/ drug therapy
Drug Synergism
Epithelial-Mesenchymal Transition
/ drug effects
Ergocalciferols
/ chemical synthesis
Fluorouracil
/ pharmacology
Gene Expression Regulation, Neoplastic
/ drug effects
HCT116 Cells
HT29 Cells
Humans
Molecular Structure
Signal Transduction
/ drug effects
Vitamin D
/ analogs & derivatives
Vitamin D3 24-Hydroxylase
/ metabolism
1,25-dihydroxyergocalciferol analogs
CYP24A1-dependent metabolism
antiproliferative activity in vitro
double-point modified vitamin D2 analogs
human colorectal cancer cell lines
vitamin D derivatives
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Jan 2020
18 Jan 2020
Historique:
received:
17
11
2019
accepted:
15
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
9
10
2020
Statut:
epublish
Résumé
Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both
Identifiants
pubmed: 31963716
pii: ijms21020642
doi: 10.3390/ijms21020642
pmc: PMC7013581
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ergocalciferols
0
Vitamin D
1406-16-2
1,25-dihydroxyvitamin D
66772-14-3
CYP24A1 protein, human
EC 1.14.15.16
Vitamin D3 24-Hydroxylase
EC 1.14.15.16
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center (Poland)
ID : DEC-2012/05/N/NZ5/00883
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