Targeted Alpha Therapy with Thorium-227.

Alpha Particles / therapeutic use Antibodies, Monoclonal / pharmacology Biomarkers, Tumor / antagonists & inhibitors DNA Breaks, Double-Stranded / radiation effects Drug Stability Humans Immunoconjugates / chemistry Molecular Targeted Therapy / methods Neoplasms / genetics Radiopharmaceuticals / chemistry Thorium / chemistry Tumor Microenvironment / immunology
cancer radionuclide therapy review targeted therapy thorium-227 α-emitter

Journal

Cancer biotherapy & radiopharmaceuticals
ISSN: 1557-8852
Titre abrégé: Cancer Biother Radiopharm
Pays: United States
ID NLM: 9605408

Informations de publication

Date de publication:
Aug 2020
Historique:
pubmed: 23 1 2020
medline: 7 4 2021
entrez: 23 1 2020
Statut: ppublish

Résumé

Targeted alpha therapy (TAT) can deliver high localized burden of radiation selectively to cancer cells as well as the tumor microenvironment, while minimizing toxicity to normal surrounding cell. Radium-223 (

Identifiants

DOI: 10.1089/cbr.2019.3105 PMID: 31967907
pubmed: 31967907
doi: 10.1089/cbr.2019.3105
doi:

Substances chimiques

Antibodies, Monoclonal 0
Biomarkers, Tumor 0
Immunoconjugates 0
Radiopharmaceuticals 0
Thorium-227 0
Thorium 60YU5MIG9W

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

437-445

Auteurs

Viviana Frantellizzi (V)

Department of Molecular Medicine and Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

Laura Cosma (L)

Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

Gabriele Brunotti (G)

Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

Arianna Pani (A)

Department of Oncology and Hemato-oncology, University of Milan "Statale," Milan, Italy.

Angela Spanu (A)

Unit of Nuclear Medicine, Department of Medicine, Surgical and Experimental Science, University of Sassari, Sassari, Italy.

Susanna Nuvoli (S)

Unit of Nuclear Medicine, Department of Medicine, Surgical and Experimental Science, University of Sassari, Sassari, Italy.

Flaminia De Cristofaro (F)

Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

Liana Civitelli (L)

Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

Giuseppe De Vincentis (G)

Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Particules alpha › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Cassures de l'ADN › Cassures double-brin de l'ADN › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunoconjugués › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Tumeurs › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Thorium › Targeted Alpha Therapy with Thorium-227.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Targeted Alpha Therapy with Thorium-227.