Differential neurocognitive network perturbation in amnestic and aphasic Alzheimer disease.
Aged
Alzheimer Disease
/ diagnostic imaging
Amnesia
/ diagnostic imaging
Aniline Compounds
Aphasia
/ diagnostic imaging
Brain
/ diagnostic imaging
Cognition
/ physiology
Ethylene Glycols
Female
Humans
Magnetic Resonance Imaging
Male
Neural Pathways
/ diagnostic imaging
Positron-Emission Tomography
Radiopharmaceuticals
Rest
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
18 02 2020
18 02 2020
Historique:
received:
23
03
2019
accepted:
20
08
2019
pubmed:
24
1
2020
medline:
15
5
2020
entrez:
24
1
2020
Statut:
ppublish
Résumé
To determine if Alzheimer disease (AD) is associated with aphasic rather than amnestic dementias in certain circumstances related in part to perturbations in different networks. Three groups were investigated: 14 participants suspected of having the neuropathology of AD based on clinically diagnosed amnestic dementia of the Alzheimer type (DAT), 26 individuals with primary progressive aphasia (PPA) with either a positive Greater connectivity perturbations were found from the hippocampus for the DAT group and from the IFG for the PPA group. Furthermore, connectivity alterations in the PPA group were more asymmetric and favored the language-dominant left hemisphere. Loss of connectivity from the DMN seed was of a similar magnitude in the PPA and DAT groups. Despite the presumptive common underlying neuropathology of amyloid plaques and neurofibrillary tangles, the 2 groups displayed 2 different patterns of network perturbation, each concordant with the clinical presentation and the anatomy of neurodegeneration.
Identifiants
pubmed: 31969462
pii: WNL.0000000000008960
doi: 10.1212/WNL.0000000000008960
pmc: PMC7176298
doi:
Substances chimiques
Aniline Compounds
0
Ethylene Glycols
0
Radiopharmaceuticals
0
florbetapir
6867Q6IKOD
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e699-e704Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG020506
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Informations de copyright
© 2020 American Academy of Neurology.
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