The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function.
Bone Diseases
/ metabolism
Bone and Bones
/ metabolism
Cell Cycle Proteins
/ metabolism
Cell Lineage
Chondrogenesis
/ physiology
Forkhead Box Protein O1
/ metabolism
Forkhead Box Protein O3
/ metabolism
Forkhead Transcription Factors
/ classification
Hematopoietic Stem Cells
Osteoarthritis
/ metabolism
Osteoblasts
/ metabolism
Osteoclasts
/ metabolism
Osteocytes
/ metabolism
Osteogenesis
/ physiology
Osteoporosis
/ metabolism
Signal Transduction
Transcription Factors
/ metabolism
FoxOs
antioxidant
bone cells
bone diseases
chondrogenesis
osteoclastogenesis
osteogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jan 2020
21 Jan 2020
Historique:
received:
13
12
2019
revised:
16
01
2020
accepted:
17
01
2020
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4, and FoxO6, are expressed in different organs. In bone, the first three members are extensively expressed and more studied. Bone development, remodeling, and homeostasis are all regulated by multiple cell lineages, including osteoprogenitor cells, chondrocytes, osteoblasts, osteocytes, osteoclast progenitors, osteoclasts, and the intercellular signaling among these bone cells. The disordered FoxOs function in these bone cells contribute to osteoarthritis, osteoporosis, or other bone diseases. Here, we review the current literature of FoxOs for their roles in bone cells, focusing on helping researchers to develop new therapeutic approaches and prevent or treat the related bone diseases.
Identifiants
pubmed: 31973091
pii: ijms21030692
doi: 10.3390/ijms21030692
pmc: PMC7037875
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
FOXO4 protein, human
0
FOXO6 protein, human
0
Forkhead Box Protein O1
0
Forkhead Box Protein O3
0
Forkhead Transcription Factors
0
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : China Postdoctoral Science Foundation
ID : No. 2017M613210
Organisme : National Natural Science Foundation of China
ID : No.81801871
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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