Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats.
Animals
Calcium
/ metabolism
Calcium Signaling
Cells, Cultured
Coronary Vessels
/ drug effects
Disease Models, Animal
Hypertension
/ physiopathology
Male
Muscle, Smooth, Vascular
/ drug effects
Myocytes, Smooth Muscle
/ drug effects
Rats, Inbred SHR
Rats, Wistar
Receptor, Serotonin, 5-HT2A
/ drug effects
Serotonin
/ pharmacology
Serotonin 5-HT2 Receptor Agonists
/ pharmacology
Vasoconstriction
/ drug effects
5-HT
Coronary artery
Hypertension
Spontaneously hypertensive rats
Vasoconstriction
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
17
10
2019
accepted:
08
01
2020
pubmed:
26
1
2020
medline:
27
8
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Hypertension is one of the risk factors for coronary heart disease. The present study investigated the mechanism of contractile dysfunction induced by serotonin (5-HT) in coronary artery in spontaneously hypertensive rats (SHRs). Coronary arteries were isolated form SHRs and Wistar rats. Arterial ring contraction was measured using a multi myograph system. Intracellular calcium concentration was measured with a Ca
Identifiants
pubmed: 31980857
doi: 10.1007/s00210-020-01813-5
pii: 10.1007/s00210-020-01813-5
doi:
Substances chimiques
Receptor, Serotonin, 5-HT2A
0
Serotonin 5-HT2 Receptor Agonists
0
Serotonin
333DO1RDJY
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2165-2176Références
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