Emergence of clinical isolates of highly carbapenem-resistant Klebsiella pneumoniae co-harboring bla
Amikacin
/ pharmacology
Aminoglycosides
/ pharmacology
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ genetics
Carbapenem-Resistant Enterobacteriaceae
/ drug effects
Carbapenems
/ pharmacology
Genome, Bacterial
Humans
Klebsiella Infections
/ drug therapy
Klebsiella pneumoniae
/ drug effects
Microbial Sensitivity Tests
Nepal
Plasmids
/ genetics
Whole Genome Sequencing
beta-Lactamases
/ genetics
16S rRNA methylase
Carbapenemase
Klebsiella pneumoniae
Multidrug resistance
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
27
11
2019
revised:
18
01
2020
accepted:
20
01
2020
pubmed:
27
1
2020
medline:
19
3
2020
entrez:
27
1
2020
Statut:
ppublish
Résumé
The aim of this study was to describe the emergence in Nepal of clinical isolates of Klebsiella pneumoniae harboring both bla Six clinical isolates of K. pneumoniae highly resistant to carbapenems and aminoglycosides were obtained from inpatients in Nepal. Their whole genomes were sequenced by a next generation sequencer. The minimum inhibitory concentrations of meropenem, amikacin and ciprofloxacin were ≥128 μg/ml, >1024 μg/ml and ≥256 μg/ml, respectively. All six isolates co-harbored bla This is the first report of clinical isolates of K. pneumoniae co-harboring bla
Identifiants
pubmed: 31982619
pii: S1201-9712(20)30042-4
doi: 10.1016/j.ijid.2020.01.040
pii:
doi:
Substances chimiques
Aminoglycosides
0
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
Amikacin
84319SGC3C
beta-Lactamases
EC 3.5.2.6
beta-lactamase NDM-1
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
247-252Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.