Crescentic IgA nephropathy in children.
Adolescent
Case-Control Studies
Child
Disease Progression
Female
Glomerular Filtration Rate
Glomerulonephritis, IGA
/ complications
Glucocorticoids
/ therapeutic use
Humans
Immunosuppressive Agents
/ therapeutic use
Kaplan-Meier Estimate
Kidney Failure, Chronic
/ etiology
Kidney Glomerulus
/ pathology
Male
Mass Screening
Prednisolone
/ therapeutic use
Retrospective Studies
School Health Services
Crescentic IgA nephropathy
Crescents
ESRD
School screening program
Tubular atrophy
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
07
2019
accepted:
14
01
2020
revised:
23
12
2019
pubmed:
30
1
2020
medline:
5
5
2021
entrez:
30
1
2020
Statut:
ppublish
Résumé
Crescentic IgA nephropathy (C-IgAN) is defined as IgAN with more than 50% of glomeruli showing crescents. C-IgAN in children is rare; we investigate in detail for the first time. We retrospectively analyzed the 515 consecutive children who were newly diagnosed with biopsy-proven IgAN between June 1976 and May 2010. We compared clinical and pathological findings between C-IgAN and non-C-IgAN. Among 515 cases of childhood IgAN, 25 children (4.9%) had C-IgAN. Of these 25, 16 children (64%) were referred to hospitals by annual school screening. Clinical findings showed significant differences in gross hematuria (76 vs. 50%, p = .03), excretion of proteinuria (1.9 vs. 0.5 g/day/m We confirmed the importance of school screening to find C-IgAN. Although most crescents (mean: 98.1%) of C-IgAN were cellular/fibrocellular, and acute lesions were well modified with combination therapy, the presence of tubular atrophy in C-IgAN may be the reason for poorer prognosis.
Identifiants
pubmed: 31993782
doi: 10.1007/s00467-020-04483-w
pii: 10.1007/s00467-020-04483-w
doi:
Substances chimiques
Glucocorticoids
0
Immunosuppressive Agents
0
Prednisolone
9PHQ9Y1OLM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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