The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response.
Basic-Leucine Zipper Transcription Factors
/ genetics
Endoplasmic Reticulum
/ metabolism
Galactose
/ metabolism
Galactosephosphates
/ metabolism
Intracellular Signaling Peptides and Proteins
/ deficiency
Lithium
/ pharmacology
Mitochondria
/ metabolism
Oxygen Consumption
Protein Serine-Threonine Kinases
/ deficiency
RNA Splicing
Repressor Proteins
/ genetics
Saccharomyces cerevisiae
/ metabolism
Saccharomyces cerevisiae Proteins
/ genetics
Unfolded Protein Response
/ drug effects
ASPS-1
ASPSCR1
Caenorhabditis elegans (C. elegans)
Saccharomyces cerevisiae
endoplasmic reticulum stress (ER stress)
endoplasmic reticulum–associated protein degradation (ERAD)
galactose
galactosemia
lithium
mitochondria
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
received:
09
10
2019
revised:
22
01
2020
pubmed:
31
1
2020
medline:
15
12
2020
entrez:
31
1
2020
Statut:
ppublish
Résumé
In the presence of galactose, lithium ions activate the unfolded protein response (UPR) by inhibiting phosphoglucomutase activity and causing the accumulation of galactose-related metabolites, including galactose-1-phosphate. These metabolites also accumulate in humans who have the disease classic galactosemia. Here, we demonstrate that
Identifiants
pubmed: 31996377
pii: S0021-9258(17)48772-2
doi: 10.1074/jbc.RA119.011271
pmc: PMC7086034
doi:
Substances chimiques
Basic-Leucine Zipper Transcription Factors
0
Galactosephosphates
0
HAC1 protein, S cerevisiae
0
Intracellular Signaling Peptides and Proteins
0
Repressor Proteins
0
Saccharomyces cerevisiae Proteins
0
UBX4 protein, S cerevisiae
0
galactose-1-phosphate
2255-14-3
Lithium
9FN79X2M3F
SNF1-related protein kinases
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3773-3782Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Informations de copyright
© 2020 De-Souza et al.
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