Limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid.
Pseudomonas putida KT2440
catechol
cis
cis-muconic acid
fast-pyrolysis
lignin
Journal
Biotechnology and bioengineering
ISSN: 1097-0290
Titre abrégé: Biotechnol Bioeng
Pays: United States
ID NLM: 7502021
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
01
12
2019
accepted:
03
02
2020
pubmed:
6
2
2020
medline:
13
7
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Lignin is an abundant and heterogeneous waste byproduct of the cellulosic industry, which has the potential of being transformed into valuable biochemicals via microbial fermentation. In this study, we applied a fast-pyrolysis process using softwood lignin resulting in a two-phase bio-oil containing monomeric and oligomeric aromatics without syringol. We demonstrated that an additional hydrodeoxygenation step within the process leads to an enhanced thermochemical conversion of guaiacol into catechol and phenol. After steam bath distillation, Pseudomonas putida KT2440-BN6 achieved a percent yield of cis, cis-muconic acid of up to 95 mol% from catechol derived from the aqueous phase. We next established a downstream process for purifying cis, cis-muconic acid (39.9 g/L) produced in a 42.5 L fermenter using glucose and benzoate as carbon substrates. On the basis of the obtained values for each unit operation of the empirical processes, we next performed a limited life cycle and cost analysis of an integrated biotechnological and chemical process for producing adipic acid and then compared it with the conventional petrochemical route. The simulated scenarios estimate that by attaining a mixture of catechol, phenol, cresol, and guaiacol (1:0.34:0.18:0, mol ratio), a titer of 62.5 (g/L) cis, cis-muconic acid in the bioreactor, and a controlled cooling of pyrolysis gases to concentrate monomeric aromatics in the aqueous phase, the bio-based route results in a reduction of CO
Substances chimiques
Adipates
0
Phenols
0
muconic acid
3KD92ZL2KH
adipic acid
76A0JE0FKJ
Lignin
9005-53-2
Sorbic Acid
X045WJ989B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1381-1393Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 03V0757
Pays : International
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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