Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H

Animals Benzodiazepinones / administration & dosage Female Gastric Mucosa / pathology Gene Expression Profiling / methods Gene Expression Regulation / drug effects H(+)-K(+)-Exchanging ATPase / genetics Humans Hyperplasia / prevention & control In Situ Hybridization Injections, Subcutaneous Intercellular Signaling Peptides and Proteins / genetics Male Metaplasia Mice Mice, Knockout Neuroendocrine Cells / pathology Phenylurea Compounds / administration & dosage Exome Sequencing
SPEM acid inhibition gastrin netazepide neuroendocrine cells

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
31 Jan 2020
Historique:
received: 03 01 2020
revised: 28 01 2020
accepted: 29 01 2020
entrez: 7 2 2020
pubmed: 7 2 2020
medline: 18 11 2020
Statut: epublish

Résumé

Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric cancer. We have examined the effects of the gastrin receptor antagonist netazepide (NTZ) or vehicle on the gastric corpus mucosa of H

Identifiants

DOI: 10.3390/ijms21030927 PMID: 32023822 PMC: PMC7037105
pubmed: 32023822
pii: ijms21030927
doi: 10.3390/ijms21030927
pmc: PMC7037105
pii:
doi:

Substances chimiques

Benzodiazepinones 0
Intercellular Signaling Peptides and Proteins 0
Phenylurea Compounds 0
spasmolytic polypeptide 0
H(+)-K(+)-Exchanging ATPase EC 3.6.3.10
YF 476 HOU4I0G29C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Norges Teknisk-Naturvitenskapelige Universitet
ID : none
Organisme : Nowegian Gastroenterologists Association
ID : none

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Auteurs

Kristin Matre Aasarød (KM)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Gastroenterology and Hepatology, Clinic of Medicine, St Olav's University Hospital, 7491 Trondheim, Norway.

Helge Lyder Waldum (HL)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
ORCID: 0000-0002-3137-0843

Astrid Kamilla Stunes (AK)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Arne Kristian Sandvik (AK)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Gastroenterology and Hepatology, Clinic of Medicine, St Olav's University Hospital, 7491 Trondheim, Norway.
Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Arnar Flatberg (A)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Patricia Mjønes (P)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Pathology, Clinic of Laboratory Medicine, St Olav´s University Hospital, 7491 Trondheim, Norway.
ORCID: 0000-0001-7678-994X

Unni Syversen (U)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Endocrinology, Clinic of medicine, St. Olav´s University Hospital, 7491 Trondheim, Norway.

Ingunn Bakke (I)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Clinic of Medicine, St. Olav's University Hospital, 7491 Trondheim, Norway.

Reidar Fossmark (R)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Gastroenterology and Hepatology, Clinic of Medicine, St Olav's University Hospital, 7491 Trondheim, Norway.
ORCID: 0000-0002-5365-9357

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse gastrique › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › H(+)-K(+)-Exchanging ATPase › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hyperplasie › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Hybridation in situ › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections sous-cutanées › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Gastric Corpus Mucosal Hyperplasia and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Gastric Corpus Mucosal Hyperplasia and...
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questionsmedicales.fr › Cellules › Cellules endocrines › Cellules neuroendocrines › Gastric Corpus Mucosal Hyperplasia and...
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