Herb-Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats.
Administration, Oral
Animals
Down-Regulation
Gene Expression Regulation
/ drug effects
Ginsenosides
/ administration & dosage
HEK293 Cells
Herb-Drug Interactions
Humans
Liver-Specific Organic Anion Transporter 1
/ genetics
Male
Rats
Solute Carrier Organic Anion Transporter Family Member 1B3
/ genetics
Valsartan
/ administration & dosage
ginsenoside Rc
herb–drug interaction
organic anion transporting polypeptide (Oatp)
red ginseng extract (RGE)
valsartan
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
31 Jan 2020
31 Jan 2020
Historique:
received:
14
11
2019
revised:
14
01
2020
accepted:
29
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
11
11
2020
Statut:
epublish
Résumé
The purpose of this study was to investigate the herb-drug interactions involving red ginseng extract (RGE) or ginsenoside Rc with valsartan, a substrate for organic anion transporting polypeptide (OATP/Oatp) transporters. In HEK293 cells overexpressing drug transporters, the protopanaxadiol (PPD)-type ginsenosides- Rb1, Rb2, Rc, Rd, Rg3, compound K, and Rh2-inhibited human OATP1B1 and OATP1B3 transporters (IC
Identifiants
pubmed: 32023909
pii: molecules25030622
doi: 10.3390/molecules25030622
pmc: PMC7037682
pii:
doi:
Substances chimiques
Ginsenosides
0
Liver-Specific Organic Anion Transporter 1
0
SLCO1B1 protein, human
0
SLCO1B3 protein, human
0
Solute Carrier Organic Anion Transporter Family Member 1B3
0
ginsenoside Rc
0K83B0L786
ginsenoside Rb2
11021-13-9
ginsenoside Rg3
227D367Y57
ginsenoside Re
46F3R0BL3I
ginsenoside Rb1
7413S0WMH6
Valsartan
80M03YXJ7I
ginsenoside M1
A9RLM212CY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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