Influence of Severity of Type and Timing of Retrospectively Reported Childhood Maltreatment on Female Amygdala and Hippocampal Volume.
Adolescent
Adult
Adult Survivors of Child Abuse
/ statistics & numerical data
Adverse Childhood Experiences
Amygdala
/ diagnostic imaging
Case-Control Studies
Child
Child Abuse
/ psychology
Child, Preschool
Female
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Middle Aged
Organ Size
Retrospective Studies
Self Report
Severity of Illness Index
Stress Disorders, Post-Traumatic
/ diagnosis
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
received:
06
03
2019
accepted:
23
12
2019
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Deleterious effects of adverse childhood experiences (ACE) on human brain volume are widely reported. First evidence points to differential effects of ACE on brain volume in terms of timing of ACE. Upcoming studies additionally point towards the impact of different types (i.e., neglect and abuse) of ACE in terms of timing. The current study aimed to investigate the correlation between retrospectively reported severity of type (i.e., the extent to which subjects were exposed to abuse and/or neglect, respectively) and timing of ACE on female brain volume in a sample of prolonged traumatized subjects. A female sample with ACE (N = 68) underwent structural magnetic resonance imaging and a structured interview exploring the severity of ACE from age 3 up to 17 using the "Maltreatment and Abuse Chronology of Exposure" (MACE). Random forest regression with conditional interference trees was applied to assess the impact of ACE severity as well as the severity of ACE type, (i.e. to what extent individuals were exposed to neglect and/or abuse) at certain ages on pre-defined regions of interest such as the amygdala, hippocampus, and anterior cingulate (ACC) volume. Analyses revealed differential type and timing-specific effects of ACE on stress sensitive brain structures: Amygdala and hippocampal volume were affected by ACE severity during a period covering preadolescence and early adolescence. Crucially, this effect was driven by the severity of neglect.
Identifiants
pubmed: 32024861
doi: 10.1038/s41598-020-57490-0
pii: 10.1038/s41598-020-57490-0
pmc: PMC7002661
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1903Références
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