Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery.

Aged Aged, 80 and over Body Mass Index Female Follow-Up Studies Heart Disease Risk Factors Humans Ideal Body Weight Incidence Male Myocardial Infarction / epidemiology Obesity / complications Overweight / complications Postoperative Complications / epidemiology Prospective Studies Risk Factors Thinness / complications
Body mass index Obesity paradox Perioperative myocardial infarction/injury

Journal

Clinical research in cardiology : official journal of the German Cardiac Society
ISSN: 1861-0692
Titre abrégé: Clin Res Cardiol
Pays: Germany
ID NLM: 101264123

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 15 09 2019
accepted: 17 01 2020
pubmed: 7 2 2020
medline: 17 7 2021
entrez: 7 2 2020
Statut: ppublish

Résumé

The impact of obesity on the incidence of perioperative myocardial infarction/injury (PMI) and mortality following non-cardiac surgery is not well understood. We performed a prospective diagnostic study enrolling consecutive patients undergoing non-cardiac surgery, who were considered at increased cardiovascular risk. All patients were screened for PMI, defined as an absolute increase from preoperative to postoperative sensitive/high-sensitivity cardiac troponin T (hs-cTnT) concentrations. The body mass index (BMI) was classified according to the WHO classification (underweight< 18 kg/m We enrolled 4277 patients who had undergone 5413 surgeries. The median BMI was 26 kg/m Obesity class I was associated with a lower incidence of PMI, and obesity in general was associated with a lower all-cause mortality at 365 days.

Sections du résumé

BACKGROUND BACKGROUND
The impact of obesity on the incidence of perioperative myocardial infarction/injury (PMI) and mortality following non-cardiac surgery is not well understood.
METHODS METHODS
We performed a prospective diagnostic study enrolling consecutive patients undergoing non-cardiac surgery, who were considered at increased cardiovascular risk. All patients were screened for PMI, defined as an absolute increase from preoperative to postoperative sensitive/high-sensitivity cardiac troponin T (hs-cTnT) concentrations. The body mass index (BMI) was classified according to the WHO classification (underweight< 18 kg/m
RESULTS RESULTS
We enrolled 4277 patients who had undergone 5413 surgeries. The median BMI was 26 kg/m
CONCLUSION CONCLUSIONS
Obesity class I was associated with a lower incidence of PMI, and obesity in general was associated with a lower all-cause mortality at 365 days.

Identifiants

DOI: 10.1007/s00392-020-01605-0 PMID: 32025837
pubmed: 32025837
doi: 10.1007/s00392-020-01605-0
pii: 10.1007/s00392-020-01605-0
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1140-1147

Subventions

Organisme : Schweizerische Herzstiftung
ID : na
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : na
Organisme : Stiftung für kardiovaskuläre Forschung Basel
ID : na
Organisme : Roche
ID : na
Organisme : Abbott Diagnostics
ID : na
Organisme : Forschungsfond Kantonspital Aarau
ID : na

Investigateurs

Thomas Wolff (T)
Karin Wildi (K)
Alessandro Genini (A)
Raphael Twerenbold (R)
Lorraine Sazgary (L)
Luca Koechlin (L)
Desiree Wussler (D)
Tobias Breidthardt (T)
Dayana Flores (D)
Stefan Osswald (S)
Katharina Rentsch (K)

Auteurs

Reka Hidvegi (R)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Anesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.

Christian Puelacher (C)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland. christian.puelacher@usb.ch.
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. christian.puelacher@usb.ch.
ORCID: 0000-0003-3206-6349

Danielle M Gualandro (DM)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.

Andreas Lampart (A)

Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Giovanna Lurati Buse (G)

Department of Anesthesia, University Hospital Düsseldorf, Düsseldorf, Germany.

Angelika Hammerer-Lerchner (A)

Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland.

Joan Walter (J)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Anesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.

Marcel Liffert (M)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Anesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.

Daniel Bolliger (D)

Department of Anesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.

Luzius Steiner (L)

Department of Anesthesia, University Hospital Basel, University of Basel, Basel, Switzerland.

Christoph Kindler (C)

Department of Anesthesia, Kantonsspital Aarau, Aarau, Switzerland.

Jaqueline Espinola (J)

Department of Anesthesia, Kantonsspital Aarau, Aarau, Switzerland.

Ivo Strebel (I)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Johanna Gueckel (J)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Stella Marbot (S)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Ketina Arslani (K)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Jasper Boeddinghaus (J)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Thomas Nestelberger (T)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Tobias Zimmermann (T)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Michael Freese (M)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Lorenz Guerke (L)

Department of Vascular Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.

Edin Mujagic (E)

Department of Vascular Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.

Daniel Rikli (D)

Department of Traumatology and Orthopedics, University Hospital Basel, University of Basel, Basel, Switzerland.

Andreas Buser (A)

Department of Hematology and Blood Bank, University Hospital Basel, University of Basel, Basel, Switzerland.

Christian Mueller (C)

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Facteurs de risque de maladie cardiaque › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Poids idéal › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Obesity paradox and perioperative myocardial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Obesity paradox and perioperative myocardial...
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