Extrachromosomal Genetic Engineering of the Marine Diatom
Acyclic Monoterpenes
/ metabolism
Chromosomes
Cytosol
/ metabolism
Diatoms
/ genetics
Diphosphates
/ metabolism
Diterpenes
/ metabolism
Genetic Engineering
/ methods
Monoterpenes
/ metabolism
Organisms, Genetically Modified
Phosphoric Monoester Hydrolases
/ genetics
Photoperiod
Plasmids
/ genetics
Sterols
/ metabolism
Phaeodactylum tricornutum
episome
extrachromosomal expression
genetic engineering
microalgae
monoterpenoids
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
pubmed:
8
2
2020
medline:
23
2
2021
entrez:
8
2
2020
Statut:
ppublish
Résumé
Geraniol is a commercially relevant plant-derived monoterpenoid that is a main component of rose essential oil and used as insect repellent. Geraniol is also a key intermediate compound in the biosynthesis of the monoterpenoid indole alkaloids (MIAs), a group of over 2000 compounds that include high-value pharmaceuticals. As plants naturally produce extremely small amounts of these molecules and their chemical synthesis is complex, industrially sourcing these compounds is costly and inefficient. Hence, microbial hosts suitable to produce MIA precursors through synthetic biology and metabolic engineering are currently being sought. Here, we evaluated the suitability of a eukaryotic microalga, the marine diatom
Identifiants
pubmed: 32032487
doi: 10.1021/acssynbio.9b00455
doi:
Substances chimiques
Acyclic Monoterpenes
0
Diphosphates
0
Diterpenes
0
Monoterpenes
0
Sterols
0
geranyl diphosphate
0
Phosphoric Monoester Hydrolases
EC 3.1.3.2
geraniol
L837108USY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM