A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction.

Animals Disease Models, Animal Feeding Behavior / physiology Food Addiction / genetics Gene Expression Profiling Gene Expression Regulation Mice, Knockout Neural Pathways / physiology Nucleus Accumbens / physiology Prefrontal Cortex / physiology Receptor, Cannabinoid, CB1 / genetics Receptors, Dopamine D2 / genetics Synaptic Transmission Up-Regulation

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 02 2020
Historique:
received: 12 06 2019
accepted: 19 12 2019
entrez: 9 2 2020
pubmed: 9 2 2020
medline: 19 5 2020
Statut: epublish

Résumé

Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemogenetic inhibition of neuronal activity in the mPFC-NAc pathway induces compulsive food seeking. Transcriptomic analysis and genetic manipulation identified that increased dopamine D2 receptor expression in the mPFC-NAc pathway promotes the addiction-like phenotype. Our study unravels a new neurobiological mechanism underlying resilience and vulnerability to the development of food addiction, which could pave the way towards novel and efficient interventions for this disorder.

Identifiants

DOI: 10.1038/s41467-020-14458-y PMID: 32034128 PMC: PMC7005839
pubmed: 32034128
doi: 10.1038/s41467-020-14458-y
pii: 10.1038/s41467-020-14458-y
pmc: PMC7005839
doi:

Substances chimiques

DRD2 protein, mouse 0
Receptor, Cannabinoid, CB1 0
Receptors, Dopamine D2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

782

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Auteurs

Laura Domingo-Rodriguez (L)

Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
ORCID: 0000-0003-3286-6696

Inigo Ruiz de Azua (I)

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Leibniz Institute for Resilience Research, Mainz, Germany.

Eduardo Dominguez (E)

Centre for genomic regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Eric Senabre (E)

Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
ORCID: 0000-0001-8507-8154

Irene Serra (I)

Instituto Cajal, CSIC, Madrid, Spain.

Sami Kummer (S)

Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Mohit Navandar (M)

Faculty of Biology and Center of Computational Sciences, Johannes Gutenberg University, Mainz, Germany.

Sarah Baddenhausen (S)

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
ORCID: 0000-0001-9847-6960

Clementine Hofmann (C)

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, Mainz, Germany.

Raul Andero (R)

Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Bellaterra, Spain.
Unitat de Neurociència Traslacional, ParcTaulí Hospital Universitari, Institut d'Investigació i Innovació ParcTaulí (I3PT), Institut de Neurociències, UAB, Bellaterra, Spain.

Susanne Gerber (S)

Faculty of Biology and Center of Computational Sciences, Johannes Gutenberg University, Mainz, Germany.

Marta Navarrete (M)

Instituto Cajal, CSIC, Madrid, Spain.
ORCID: 0000-0003-2097-4788

Mara Dierssen (M)

Centre for genomic regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
ORCID: 0000-0003-0853-6865

Beat Lutz (B)

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Leibniz Institute for Resilience Research, Mainz, Germany.

Elena Martín-García (E)

Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
ORCID: 0000-0002-4487-3028

Rafael Maldonado (R)

Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain. rafael.maldonado@upf.edu.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. rafael.maldonado@upf.edu.
ORCID: 0000-0002-4359-8773

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Addiction à la nourriture › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Système nerveux › Voies nerveuses › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB1 › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur D2 de la dopamine › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › A specific prelimbic-nucleus accumbens pathway...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › A specific prelimbic-nucleus accumbens pathway...