Systemic β-Adrenergic Receptor Activation Augments the

Adrenergic beta-Agonists / administration & dosage Adrenergic beta-Antagonists / administration & dosage Adult Bisoprolol / administration & dosage Cell Line Cell Proliferation Cytotoxicity, Immunologic Exercise / physiology Female Graft vs Tumor Effect / immunology Hematopoietic Stem Cell Transplantation Humans Immunotherapy, Adoptive / methods Lymphocyte Activation Male Nadolol / administration & dosage Neoplasms / immunology Receptors, Adrenergic / metabolism Receptors, Antigen, T-Cell, gamma-delta / metabolism T-Lymphocytes / immunology Transplantation, Homologous Young Adult
adoptive transfer immunotherapy beta-blockers exercise exercise immunology gamma-delta t-cells

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 11 09 2019
accepted: 17 12 2019
entrez: 11 2 2020
pubmed: 11 2 2020
medline: 12 11 2020
Statut: epublish

Résumé

TCR-gamma delta (γδ) T-cells are considered important players in the graft-vs.-tumor effect following allogeneic hematopoietic cell transplantation (alloHCT) and have emerged as candidates for adoptive transfer immunotherapy in the treatment of both solid and hematological tumors. Systemic β-adrenergic receptor (β-AR) activation has been shown to mobilize TCR-γδ T-cells to the blood, potentially serving as an adjuvant for alloHCT and TCR-γδ T-cell therapy. We investigated if systemic β-AR activation, using acute dynamic exercise as an experimental model, can increase the mobilization,

Identifiants

DOI: 10.3389/fimmu.2019.03082 PMID: 32038628 PMC: PMC6993603
pubmed: 32038628
doi: 10.3389/fimmu.2019.03082
pmc: PMC6993603
doi:

Substances chimiques

Adrenergic beta-Agonists 0
Adrenergic beta-Antagonists 0
Receptors, Adrenergic 0
Receptors, Antigen, T-Cell, gamma-delta 0
T-cell receptor Vdelta2, human 0
TCRVgamma9 protein, human 0
Nadolol 42200-33-9
Bisoprolol Y41JS2NL6U

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

3082

Subventions

Organisme : NCI NIH HHS
ID : R21 CA197527
Pays : United States

Informations de copyright

Copyright © 2020 Baker, Bigley, Agha, Pedlar, O'Connor, Bond, Bollard, Katsanis and Simpson.

Références

Expert Opin Biol Ther. 2019 Sep;19(9):887-895
pubmed: 31220420
Cytotherapy. 2012 Oct;14(9):1110-8
pubmed: 22800570
Brain Behav Immun. 2009 Aug;23(6):767-75
pubmed: 19254756
Brain Behav Immun. 2009 Aug;23(6):823-9
pubmed: 19318122
Blood Rev. 2016 May;30(3):179-88
pubmed: 26654098
Med Sci Sports Exerc. 1990 Dec;22(6):863-70
pubmed: 2287267
Exerc Sport Sci Rev. 2017 Jul;45(3):163-172
pubmed: 28418996
Physiol Behav. 2018 Oct 1;194:260-267
pubmed: 29885920
Front Immunol. 2018 Apr 16;9:648
pubmed: 29713319
Oncoimmunology. 2016 Sep 27;6(2):e1216291
pubmed: 28344861
Eur J Immunol. 2013 Dec;43(12):3175-82
pubmed: 24019170
Cell Death Differ. 2015 Jan;22(1):96-107
pubmed: 25168239
Brain Behav Immun. 2018 Nov;74:143-153
pubmed: 30172948
J Transl Med. 2014 Feb 15;12:45
pubmed: 24528541
Medicine (Baltimore). 2016 Sep;95(39):e4909
pubmed: 27684826
Br J Haematol. 2009 Jan;144(2):245-50
pubmed: 19016713
Cytotherapy. 2008;10(8):842-56
pubmed: 19016372
Physiol Behav. 2018 Oct 1;194:56-65
pubmed: 29723594
J Immunother Cancer. 2017 Apr 18;5:30
pubmed: 28428879
Brain Behav Immun. 2014 Jul;39:160-71
pubmed: 24200514
Prog Mol Biol Transl Sci. 2015;135:355-80
pubmed: 26477922
Blood. 2000 Jul 15;96(2):384-92
pubmed: 10887096
Sci Rep. 2016 May 16;6:25852
pubmed: 27181409
Expert Opin Pharmacother. 2014 Jan;15(1):23-36
pubmed: 24156789
J Immunol Methods. 2009 Aug 15;347(1-2):12-8
pubmed: 19465023
Front Immunol. 2015 Jan 21;6:3
pubmed: 25653652
Biol Blood Marrow Transplant. 2015 Jan;21(1):130-6
pubmed: 25445640
Oncoimmunology. 2015 Jan 22;4(3):e992749
pubmed: 25949914
F1000Res. 2017 Jun 5;6:
pubmed: 28649364
Cell Immunol. 2015 May;295(1):52-9
pubmed: 25749006
Cytotherapy. 2011 Jul;13(6):753-64
pubmed: 21314241
J Vis Exp. 2011 Sep 09;(55):
pubmed: 21931292
PLoS One. 2013 Aug 07;8(8):e68729
pubmed: 23950874
Front Immunol. 2014 Dec 08;5:622
pubmed: 25538706
Bone Marrow Transplant. 2007 Jun;39(12):751-7
pubmed: 17450185
Front Immunol. 2018 Apr 19;9:800
pubmed: 29725332
J Appl Physiol (1985). 2019 Apr 1;126(4):842-853
pubmed: 30382809
J Exp Med. 2003 Aug 4;198(3):391-7
pubmed: 12900516
Blood. 2015 Apr 9;125(15):2349-58
pubmed: 25612623
Blood. 2003 Jul 1;102(1):200-6
pubmed: 12623838
Nat Rev Immunol. 2013 Feb;13(2):88-100
pubmed: 23348415
J Immunol. 2001 May 1;166(9):5508-14
pubmed: 11313389
Br J Clin Pharmacol. 1994 Aug;38(2):103-8
pubmed: 7981009
Front Immunol. 2017 Jun 30;8:761
pubmed: 28713381
Oncoimmunology. 2013 Mar 1;2(3):e23304
pubmed: 23802074
J Immunol. 1998 May 15;160(10):4951-60
pubmed: 9590243
Cell Immunol. 2013 Jul-Aug;284(1-2):91-7
pubmed: 23954795
Cancer Res. 2005 Aug 15;65(16):7502-8
pubmed: 16103105
J Immunol. 2013 Aug 1;191(3):1346-55
pubmed: 23794630
Front Immunol. 2018 Jun 08;9:1305
pubmed: 29937769
Brain Behav Immun. 2010 May;24(4):608-14
pubmed: 20060888

Auteurs

Forrest L Baker (FL)

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, United States.
Department of Nutritional Sciences, University of Arizona, Tucson, AZ, United States.
Department of Pediatrics, University of Arizona, Tucson, AZ, United States.

Austin B Bigley (AB)

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, United States.

Nadia H Agha (NH)

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, United States.

Charles R Pedlar (CR)

School of Sport, Health and Applied Science, St. Mary's University, London, United Kingdom.

Daniel P O'Connor (DP)

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, United States.

Richard A Bond (RA)

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, United States.

Catherine M Bollard (CM)

Center for Cancer and Immunology Research, Children's National Health System and the George Washington University, Washington, DC, United States.

Emmanuel Katsanis (E)

Department of Pediatrics, University of Arizona, Tucson, AZ, United States.
Department of Immunobiology, University of Arizona, Tucson, AZ, United States.

Richard J Simpson (RJ)

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, United States.
Department of Nutritional Sciences, University of Arizona, Tucson, AZ, United States.
Department of Pediatrics, University of Arizona, Tucson, AZ, United States.
Department of Immunobiology, University of Arizona, Tucson, AZ, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes bêta-adrénergiques › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes bêta-adrénergiques › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Propanolamines › Phénoxypropanolamines › Bisoprolol › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Activités humaines › Exercice physique › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction du greffon contre l'hôte › Réaction du greffon contre la tumeur › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Propanolamines › Phénoxypropanolamines › Nadolol › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Tumeurs › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Récepteur lymphocytaire T antigène, gamma-delta › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Systemic β-Adrenergic Receptor Activation Augments the
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Systemic β-Adrenergic Receptor Activation Augments the