Influence of lung transplantation on the essential fatty acid profile in cystic fibrosis.
Cystic fibrosis
Essential fatty acid
Lung transplantation
Polyunsaturated fatty acids
Journal
Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
15
09
2019
revised:
05
12
2019
accepted:
21
01
2020
pubmed:
12
2
2020
medline:
29
5
2021
entrez:
12
2
2020
Statut:
ppublish
Résumé
Lung transplantation is assumed to normalize essential fatty acid (EFA) profile in the plasma, described as abnormal in patients with cystic fibrosis (CF). This study sought to evaluate the EFA profile in both the plasma and erythrocyte membrane according to lung status by comparing CF patients with or without a lung transplant. A total of 50 homozygous F508del patients (33 CF patients [CF group] and 17 CF patients with a lung transplant [TX CF group]) were included. In comparison with the CF group, in the plasma, the levels of total n-3, α-linolenic, eicosapentaenoic, and docosahexaenoic acids were higher and the n-6/n-3 ratio was lower in the TX CF group. Yet, these differences were not observed in the erythrocyte membrane. This study supports that lung transplantation improves the EFA profile in the plasma but not in the erythrocyte membrane by means of the different mechanisms suggested in this article.
Identifiants
pubmed: 32044180
pii: S0952-3278(19)30182-6
doi: 10.1016/j.plefa.2020.102060
pii:
doi:
Substances chimiques
Fatty Acids, Essential
0
Types de publication
Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102060Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors state that they have no conflicts of interest to declare.