Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint.
APC/C
Bub1
CCAN
Cdc20
Cdk1
MCC
Mad1
Mad2
Mps1
SAC.
spindle assembly checkpoint
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
21
01
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
28
10
2020
Statut:
epublish
Résumé
The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere, have to interact with microtubules of the mitotic spindle so that each chromatid takes connections with microtubules emanating from opposite spindle poles (we will refer to this condition as bipolar attachment). Only once all replicated chromosomes have reached bipolar attachments can sister chromatids lose cohesion with each other, at the onset of anaphase, and move toward opposite spindle poles, being segregated into what will soon become the daughter cell nucleus. Prevention of errors in chromosome segregation is granted by a safeguard mechanism called Spindle Assembly Checkpoint (SAC). Until all chromosomes are bipolarly oriented at the equator of the mitotic spindle, the SAC prevents loss of sister chromatid cohesion, thus anaphase onset, and maintains the mitotic state by inhibiting inactivation of the major M phase promoting kinase, the cyclin B-cdk1 complex (Cdk1). Here, we review recent mechanistic insights about the circuitry that links Cdk1 to the SAC to ensure correct achievement of the goal of mitosis.
Identifiants
pubmed: 32047615
doi: 10.12688/f1000research.21185.1
pmc: PMC6993828
pii:
doi:
Substances chimiques
CDC2 Protein Kinase
EC 2.7.11.22
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright: © 2020 Serpico AF and Grieco D.
Déclaration de conflit d'intérêts
No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.
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