The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
28 02 2020
28 02 2020
Historique:
pubmed:
13
2
2020
medline:
12
2
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
Dithiolopyrrolones are microbial natural products containing a disulfide or thiosulfonate bridge embedded in a unique bicyclic structure. By interfering with zinc ion homeostasis in living cells, they show strong antibacterial activity against a variety of bacterial pathogens, as well as potent cytotoxicity against human cancer cells. In the current study, two new dithiolopyrrolones, pyrroloformamide C (
Identifiants
pubmed: 32049520
doi: 10.1021/acs.jnatprod.9b00321
pmc: PMC7577424
mid: NIHMS1637631
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Biological Products
0
Formamides
0
Heterocyclic Compounds, 2-Ring
0
Lactams
0
N-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-N-methylformamide
0
holomycin
44CF65YLF8
Peptide Synthases
EC 6.3.2.-
non-ribosomal peptide synthase
EC 6.3.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
202-209Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM134954
Pays : United States
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