Exercise and insulin-like growth factor 1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.
Animals
Cytokines
/ metabolism
Diabetes Mellitus, Experimental
/ metabolism
Diabetic Neuropathies
/ metabolism
Insulin-Like Growth Factor I
/ therapeutic use
Male
NF-kappa B
/ metabolism
Neovascularization, Physiologic
Physical Conditioning, Animal
/ physiology
Rats
Rats, Wistar
Sciatic Nerve
/ metabolism
Thrombospondin 1
/ metabolism
Vascular Endothelial Growth Factor A
/ metabolism
angiogenesis
diabetic neuropathy
nuclear factor-κB
sciatic nerve
thrombospondin-1
vascular endothelial growth factor-A
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
31
07
2019
accepted:
11
02
2020
pubmed:
14
2
2020
medline:
9
9
2021
entrez:
14
2
2020
Statut:
ppublish
Résumé
What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat? Can exercise and insulin-like growth factor 1 (IGF-I) treatment improve the diabetes-related decrease in angiogenesis in sciatic nerve in these animals? What is the main finding and its importance? Levels of VEGF-A, TSP-1 and NF-κB change in the sciatic nerve of diabetic rats and might mediate diabetic neuropathy. Treatment with IGF-I and exercise could increase angiogenesis in the diabetic rats by increasing VEGF-A and decreasing TSP-1 and NF-κB expression in the sciatic nerve. Diabetic neuropathy is a severe complication of diabetes that affects 40-50% of diabetic people in the world. The aim of this study was to characterize alterations in angiogenesis and related molecular mediators in the sciatic nerve in diabetic conditions alone or in diabetes in combination with exercise and/or administration of insulin-like growth factor 1 (IGF-I). Forty male Wistar rats were assigned into one of five groups, namely control, diabetes, diabetes + exercise, diabetes + IGF-I and diabetes + exercise + IGF-I. Type 1 diabetes was induced by i.p. injection of streptozotocin (60 mg kg
Substances chimiques
Cytokines
0
NF-kappa B
0
Thrombospondin 1
0
Vascular Endothelial Growth Factor A
0
thrombospondin 1, rat
0
vascular endothelial growth factor A, rat
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-792Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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